FCGR2A
This gene encodes one member of a family of immunoglobulin Fc receptor genes found on the surface of many immune response cells. The protein encoded by this gene is a cell surface receptor found on phagocytic cells such as macrophages and neutrophils, and is involved in the process of phagocytosis and clearing of immune complexes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2008]
Full Name
Fc Fragment Of IgG Receptor IIa
Research Area
Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens.
Biological Process
Cell surface receptor signaling pathway Source: GO_Central
Immune system process Source: UniProtKB-KW
Regulation of immune response Source: GO_Central
Immune system process Source: UniProtKB-KW
Regulation of immune response Source: GO_Central
Cellular Location
Cell membrane
Topology
Extracellular: 34-217
Helical: 218-240
Cytoplasmic: 241-317
Helical: 218-240
Cytoplasmic: 241-317
PTM
Phosphorylated by SRC-type Tyr-kinases such as LYN, BLK, FYN, HCK and SYK.
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Anti-FCGR2A antibodies
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Target: FCGR2A
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-217
Tag: His Tag
Target: FCGR2A
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-217
Tag: His & AVI Tag
Target: FCGR2A
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-216
Tag: His Tag
Target: FCGR2A
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-216
Tag: hFc Tag
Target: FCGR2A
Expressed Host: CHO Cells
Sequence: Amino Acid: 1-218
Tag: His Tag
Target: FCGR2A
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-218
Tag: His Tag
Compare
Target: FCGR2A
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-210
Tag: His & AVI Tag
Target: FCGR2A
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-218
Tag: hFc Tag
Target: FCGR2A
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-218
Tag: His Tag
Target: FCGR2A
Expressed Host: CHO Cells
Sequence: Amino Acid: 1-218
Tag: His Tag
Compare
Target: FCGR2A
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 36-210
Tag: His & AVI Tag
Compare
Target: FCGR2A
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-210
Tag: His & AVI Tag
Target: FCGR2A
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-211
Tag: His Tag
Target: FCGR2A
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-220
Tag: His & AVI Tag
Target: FCGR2A
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-220
Tag: hFc Tag
Target: FCGR2A
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 3B6
Application*: E, WB
Target: FCGR2A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 9
Application*: B
Target: FCGR2A
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXF-1279
Application*: E, F, B, IF, IP
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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