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Mouse Anti-FCGR2A Recombinant Antibody (20D1) (CBMAB-F1537-CQ)

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Datasheet
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Basic Information

Host Animal
Mouse
Clone
20D1
Application
IHC, WB
Immunogen
A protein expressed in 293T cell transfected with human FCGR2A expression vector
Specificity
Human, Monkey
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.3, 1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
Fc Fragment Of IgG Receptor IIa
Introduction
This gene encodes one member of a family of immunoglobulin Fc receptor genes found on the surface of many immune response cells. The protein encoded by this gene is a cell surface receptor found on phagocytic cells such as macrophages and neutrophils, and is involved in the process of phagocytosis and clearing of immune complexes. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
Human2212
Monkey719996
UniProt ID
HumanP12318
MonkeyH9BMP0
Alternative Names
Fc Fragment Of IgG Receptor IIa; Fc Fragment Of IgG, Low Affinity IIa, Receptor (CD32); Immunoglobulin G Fc Receptor II; IgG Fc Receptor II-A; Fc-Gamma-RIIa; FcRII-A; FCGR2A1; CDw32; IGFR2; FCG2;
Research Area
Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens.
Biological Process
Cell surface receptor signaling pathway Source: GO_Central
Immune system process Source: UniProtKB-KW
Regulation of immune response Source: GO_Central
Cellular Location
Cell membrane
Topology
Extracellular: 34-217
Helical: 218-240
Cytoplasmic: 241-317
PTM
Phosphorylated by SRC-type Tyr-kinases such as LYN, BLK, FYN, HCK and SYK.

Dahlqvist, J., Fulco, C. P., Ray, J. P., Liechti, T., de Boer, C. G., Lieb, D. J., ... & Hacohen, N. (2022). Systematic identification of genomic elements that regulate FCGR2A expression and harbor variants linked with autoimmune disease. Human Molecular Genetics, 31(12), 1946-1961.

Paul, P., Picard, C., Lyonnet, L., Resseguier, N., Hubert, L., Arnaud, L., ... & Bonello, L. (2022). FCGR2A-HH Gene Variants Encoding the Fc Gamma Receptor for the C-Reactive Protein Are Associated with Enhanced Monocyte CD32 Expression and Cardiovascular Events’ Recurrence after Primary Acute Coronary Syndrome. Biomedicines, 10(2), 495.

Márquez Pete, N., Maldonado Montoro, M. D. M., Pérez Ramírez, C., Martínez Martínez, F., Martínez de la Plata, J. E., Daddaoua, A., & Jiménez Morales, A. (2021). Influence of the FCGR2A rs1801274 and FCGR3A rs396991 Polymorphisms on Response to Abatacept in Patients with Rheumatoid Arthritis. Journal of personalized medicine, 11(6), 573.

Ferdosian, F., Dastgheib, S. A., Hosseini-Jangjou, S. H., Nafei, Z., Lookzadeh, M. H., Noorishadkam, M., ... & Neamatzadeh, H. (2021). Association of TNF-α rs1800629, CASP3 rs72689236 and FCGR2A rs1801274 polymorphisms with susceptibility to Kawasaki disease: a comprehensive meta-analysis. Fetal and pediatric pathology, 40(4), 320-336.

Dai, Y., Chen, W., Huang, J., & Cui, T. (2021). FCGR2A Could Function as a Prognostic Marker and Correlate with Immune Infiltration in Head and Neck Squamous Cell Carcinoma. BioMed Research International, 2021.

Shi, X., Ma, Y., Li, H., & Yu, H. (2020). Association between FCGR2A rs1801274 and MUC5B rs35705950 variations and pneumonia susceptibility. BMC medical genetics, 21(1), 1-13.

Sim, B. K., Park, H., Kim, J. J., Yun, S. W., Yu, J. J., Yoon, K. L., ... & Lee, J. K. (2019). Assessment of the clinical heterogeneity of Kawasaki disease using genetic variants of BLK and FCGR2A. Korean Circulation Journal, 49(1), 99-108.

Paul, P., Pedini, P., Lyonnet, L., Di Cristofaro, J., Loundou, A., Pelardy, M., ... & Picard, C. (2019). FCGR3A and FCGR2A genotypes differentially impact allograft rejection and patients' survival after lung transplant. Frontiers in Immunology, 10, 1208.

Jiménez Morales, A., Maldonado‐Montoro, M., Martinez de la Plata, J. E., Pérez Ramírez, C., Daddaoua, A., Alarcón Payer, C., ... & Garcia Collado, C. (2019). FCGR2A/FCGR3A gene polymorphisms and clinical variables as predictors of response to tocilizumab and rituximab in patients with rheumatoid arthritis. The Journal of Clinical Pharmacology, 59(4), 517-531.

Xia, S. L., Lin, D. P., Lin, Q. R., Sun, L., Wang, X. Q., Hong, W. J., ... & Jiang, Y. (2018). A Case–Control Study on Association of Ulcerative Colitis with FCGR2A Gene Polymorphisms in Chinese Patients. Genetic Testing and Molecular Biomarkers, 22(10), 607-614.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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