FCGR3A
This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Full Name
Fc Fragment Of IgG Receptor IIIa
Alternative Names
Fc Fragment Of IgG Receptor IIIa; Fc Fragment Of IgG; Low Affinity IIIa; Receptor (CD16a); Fc Gamma Receptor IIIa; IgG Fc Receptor III-2; Fc-Gamma RIII-Alpha; Fc-Gamma RIIIa; Fc-Gamma RIII; CD16a Antigen; FCRIIIA; FCR-10; FCRIII; FCGR3; CD16A; IGFR3; FCG3;
Research Area
Receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis.
Biological Process
Cell surface receptor signaling pathway Source: GO_Central
Immune response Source: ProtInc
Regulation of immune response Source: GO_Central
Immune response Source: ProtInc
Regulation of immune response Source: GO_Central
Cellular Location
Secreted; Cell membrane. Exists also as a soluble receptor.
Involvement in disease
Immunodeficiency 20 (IMD20):
A rare autosomal recessive primary immunodeficiency characterized by functional deficiency of NK cells. Affected individuals typically present with severe herpes viral infections, particularly Epstein Barr virus (EBV), and human papillomavirus (HPV).
A rare autosomal recessive primary immunodeficiency characterized by functional deficiency of NK cells. Affected individuals typically present with severe herpes viral infections, particularly Epstein Barr virus (EBV), and human papillomavirus (HPV).
Topology
Extracellular: 17-208
Helical: 209-229
Cytoplasmic: 230-254
Helical: 209-229
Cytoplasmic: 230-254
PTM
Glycosylated. Contains high mannose- and complex-type oligosaccharides. Glycosylation at Asn-180 is mandatory for high affinity binding to the Fc and for discrimination between fucosylated and afucosylated IgG glycoforms.
The soluble form is produced by a proteolytic cleavage.
The soluble form is produced by a proteolytic cleavage.
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Anti-FCGR3A antibodies
+ Filters
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CompareTarget: FCGR3A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C1194
Application*: F, IF
Target: FCGR3A
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Baboon
Clone: AG70
Application*: B, MC, F, C, IP
Target: FCGR3A
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: AT154-2
Application*: C
Target: FCGR3A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Pig
Clone: 3H1027
Application*: F
Target: FCGR3A
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: 5B11
Application*: E, F, IF, IH, IP
Target: FCGR3A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: 4B1H6
Application*: E, WB
Target: FCGR3A
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: 15
Application*: E, WB
Target: FCGR3A
Host: Rat
Antibody Isotype: IgG
Specificity: Mouse
Clone: 14G3
Application*: F, IF, IP
Target: FCGR3A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Monkey
Clone: 1
Application*: E
Target: FCGR3A
Host: Rabbit
Antibody Isotype: IgG
Specificity: Rat
Clone: 041
Application*: E
Target: FCGR3A
Host: Rat
Antibody Isotype: IgG2b, κ
Specificity: Mouse
Clone: 2.4G2
Application*: B, F, C
Target: FCGR3A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2776
Application*: F
Target: FCGR3A
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT17
Application*: WB, P, IF
Target: FCGR3A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: A133
Application*: FC, IF
Target: FCGR3A
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CAP751
Application*: ELISA, WB
Target: FCGR3A
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: 2.4G2
Application*: Block, FC, IF, IHC, IP
Target: FCGR3A
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CAP750
Application*: WB
Target: FCGR3A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: MEM154
Application*: FC
Target: FCGR3A
Host: Mouse
Specificity: Human
Clone: IHC528
Application*: IH
Target: FCGR3A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CB-16
Application*: F
Target: FCGR3A
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: D1N9L
Application*: IH, P
Target: FCGR3A
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: D8W2O
Application*: WB
Target: FCGR3A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 7E6-D1
Application*: F
Target: FCGR3A
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 5D7
Application*: F
Target: FCGR3A
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: MEM-168
Application*: F
Target: FCGR3A
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: Q32
Application*: WB
Target: FCGR3A
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: NKP15
Application*: F
Target: FCGR3A
Host: Rat
Antibody Isotype: IgG2b
Specificity: Human
Clone: YFC120.5
Application*: IH, FC
Target: FCGR3A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 9F605
Application*: E
Target: FCGR3A
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 2Q1243
Application*: IF, IH, WB
Target: FCGR3A
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 13H52
Application*: FC, IF
Target: FCGR3A
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 10K42
Application*: FC
Target: FCGR3A
Host: Rabbit
Antibody Isotype: IgG2b
Specificity: Cat, Human
Clone: 10B815
Application*: FC, IH
Target: FCGR3A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 10B814
Application*: FC, IH
Target: FCGR3A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-3697
Application*: F
Target: FCGR3A
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: LNK16/MEM-188
Application*: F
Target: FCGR3A
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: ICO-116
Application*: F, IF
Target: FCGR3A
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human
Clone: CBWJC-3696
Application*: F
Target: FCGR3A
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: CBWJC-3695
Application*: F
Target: FCGR3A
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Pig
Clone: CBWJC-3694
Application*: F
Target: FCGR3A
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBWJC-3692
Application*: F
Target: FCGR3A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: c127
Application*: C, F, IP
Target: FCGR3A
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: CBWJC-3691
Application*: F, IH, IP
Target: FCGR3A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-3690
Application*: C
Target: FCGR3A
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBWJC-3689
Application*: F, IF, IH
Target: FCGR3A
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBWJC-3688
Application*: E, WB
Target: FCGR3A
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Rat
Clone: CBWJC-3687
Application*: E, F, IF, C, IP
Target: FCGR3A
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBWJC-3686
Application*: B
Target: FCGR3A
Host: Armenian Hamster
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBWJC-3685
Application*: F
Target: FCGR3A
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: KT1632
Application*: F
Target: FCGR3A
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Cattle, Human, Sheep
Clone: KD1
Application*: F, N
Target: FCGR3A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: J5511
Application*: F
Target: FCGR3A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: HI16a
Application*: E, F, IH
Target: FCGR3A
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBWJC-2161
Application*: F, IH, IP, WB, E
Target: FCGR3A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Pig
Clone: G7
Application*: F, IF, IP
Target: FCGR3A
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBWJC-2160
Application*: WB, IC
Target: FCGR3A
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBWJC-2159
Application*: F
Target: FCGR3A
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: B73.1
Application*: F
Target: FCGR3A
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: CBWJC-2157
Application*: F, C
Target: FCGR3A
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: VEP13
Application*: F
Target: FCGR3A
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXC-1823
Application*: F
Target: FCGR3A
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: GRM1
Application*: F, C, IP, WB
Target: FCGR3A
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXC-0649
Application*: F, C, WB
Target: FCGR3A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-2204
Application*: F, IP, C, FN
Target: FCGR3A
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: ASH 1975
Application*: E, F, IF, C, IP
Target: FCGR3A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C2488
Application*: E
Target: FCGR3A
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: CBYY-C1193
Application*: F
Target: FCGR3A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Pig
Clone: CBYY-C1192
Application*: F
Target: FCGR3A
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-C1191
Application*: IH
Target: FCGR3A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C0601
Application*: F
Target: FCGR3A
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-C0443
Application*: F, IH, IP, WB
Target: FCGR3A
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-C0376
Application*: F, IF, IH
Target: FCGR3A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C0088
Application*: F, IP
Target: FCGR3A
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYC-2693
Application*: WB
Target: FCGR3A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-2692
Application*: E
Target: FCGR3A
Host: Rabbit
Antibody Isotype: IgG
Specificity: Rat
Clone: CBFYC-2691
Application*: E
Target: FCGR3A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-2690
Application*: P
Target: FCGR3A
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: CBFYC-2689
Application*: F
Target: FCGR3A
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYC-2688
Application*: E, WB
Target: FCGR3A
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYC-2687
Application*: F, IF, IH, IP
Target: FCGR3A
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYC-2686
Application*: F, IF
Target: FCGR3A
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: CBFYC-2685
Application*: F
Target: FCGR3A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-0191
Application*: F
Target: FCGR3A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: MEM-154
Application*: E, C, FN, WB
Target: FCGR3A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 8.F.39
Application*: F, IF
Target: FCGR3A
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 5K230
Application*: F, IH, IP, WB
Target: FCGR3A
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 5F19
Application*: F, IF, IH
Target: FCGR3A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5B12
Application*: F
Target: FCGR3A
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: 4P29
Application*: F
Target: FCGR3A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4C9C3C4
Application*: E
Target: FCGR3A
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 3H1026
Application*: IH
Target: FCGR3A
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2B11
Application*: E, WB
Target: FCGR3A
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 2B1
Application*: WB
Target: FCGR3A
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: 14L165
Application*: F
Target: FCGR3A
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 13H51
Application*: F, IF, IH, IP
Target: FCGR3A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 05
Application*: E
Target: FCGR3A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 04
Application*: P
Target: FCGR3A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3H1029
Application*: F, IP
Target: FCGR3A
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 2H7
Application*: P
Target: FCGR3A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-2926
Application*: E, WB
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(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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