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Rabbit Anti-FCGR3A Recombinant Antibody (041) (CBMAB-C1759-LY)

This product is antibody recognizes FCGR3A. The antibody 041 immunoassay techniques such as: ELISA.
See all FCGR3A antibodies

Summary

Host Animal
Rabbit
Specificity
Rat
Clone
041
Antibody Isotype
IgG
Application
ELISA

Basic Information

Immunogen
Recombinant Rat CD16a / FCGR3A protein
Specificity
Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Fc Fragment Of IgG Receptor IIIa
Introduction
This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Entrez Gene ID
UniProt ID
Research Area
Receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis.
Biological Process
Cell surface receptor signaling pathway Source: GO_Central
Immune response Source: ProtInc
Regulation of immune response Source: GO_Central
Cellular Location
Secreted; Cell membrane. Exists also as a soluble receptor.
Involvement in disease
Immunodeficiency 20 (IMD20):
A rare autosomal recessive primary immunodeficiency characterized by functional deficiency of NK cells. Affected individuals typically present with severe herpes viral infections, particularly Epstein Barr virus (EBV), and human papillomavirus (HPV).
Topology
Extracellular: 17-208
Helical: 209-229
Cytoplasmic: 230-254
PTM
Glycosylated. Contains high mannose- and complex-type oligosaccharides. Glycosylation at Asn-180 is mandatory for high affinity binding to the Fc and for discrimination between fucosylated and afucosylated IgG glycoforms.
The soluble form is produced by a proteolytic cleavage.

Ebonwu, J., Lassaunière, R., Paximadis, M., Strehlau, R., Gray, G. E., Kuhn, L., & Tiemessen, C. T. (2022). FCGR3A gene duplication, FcγRIIb-232TT and FcγRIIIb-HNA1a associate with an increased risk of vertical acquisition of HIV-1. Plos one, 17(9), e0273933.

Sun, K., Fei, X., Xu, M., Xu, R., & Xu, M. (2022). FCGR3A Is a Prognostic Biomarker and Correlated with Immune Infiltrates in Lower-Grade Glioma. Journal of Oncology, 2022.

Litjens, N., Peeters, A., Gestel, J. K. V., Klepper, M., & Betjes, M. (2021). The FCGR3A 158 V/V-genotype is associated with decreased survival of renal allografts with chronic active antibody-mediated rejection. Scientific Reports, 11(1), 1-11.

Márquez Pete, N., Maldonado Montoro, M. D. M., Pérez Ramírez, C., Martínez Martínez, F., Martínez de la Plata, J. E., Daddaoua, A., & Jiménez Morales, A. (2021). Influence of the FCGR2A rs1801274 and FCGR3A rs396991 Polymorphisms on Response to Abatacept in Patients with Rheumatoid Arthritis. Journal of personalized medicine, 11(6), 573.

Izadi, N., Sun, M., Mace, E. M., O’Gorman, M. R., & Church, J. A. (2021). Undetectable NK Cells due to the FCGR3A Variant, L66H, Which May Not Be Directly Disease-Causing. Journal of Clinical Immunology, 41(8), 1957-1959.

Liu, B., Maier, L. A., Hamzeh, N., MacPhail, K., Mroz, M. M., Liu, H., & Li, L. (2019). Polymorphism of FCGR3A gene in chronic beryllium disease. Genes & Immunity, 20(6), 493-499.

Paul, P., Pedini, P., Lyonnet, L., Di Cristofaro, J., Loundou, A., Pelardy, M., ... & Picard, C. (2019). FCGR3A and FCGR2A genotypes differentially impact allograft rejection and patients' survival after lung transplant. Frontiers in Immunology, 10, 1208.

Jiménez Morales, A., Maldonado‐Montoro, M., Martinez de la Plata, J. E., Pérez Ramírez, C., Daddaoua, A., Alarcón Payer, C., ... & Garcia Collado, C. (2019). FCGR2A/FCGR3A gene polymorphisms and clinical variables as predictors of response to tocilizumab and rituximab in patients with rheumatoid arthritis. The Journal of Clinical Pharmacology, 59(4), 517-531.

Mahaweni, N. M., Olieslagers, T. I., Rivas, I. O., Molenbroeck, S. J., Groeneweg, M., Bos, G. M., ... & Wieten, L. (2018). A comprehensive overview of FCGR3A gene variability by full-length gene sequencing including the identification of V158F polymorphism. Scientific reports, 8(1), 1-11.

Romero-Cara, P., Torres-Moreno, D., Pedregosa, J., Vílchez, J. A., García-Simón, M. S., Ruiz-Merino, G., ... & Conesa-Zamora, P. (2018). A FCGR3A polymorphism predicts anti-drug antibodies in chronic inflammatory bowel disease patients treated with anti-TNF. International journal of medical sciences, 15(1), 10.

Sun, K., Fei, X., Xu, M., Xu, R., & Xu, M. (2022). FCGR3A Is a Prognostic Biomarker and Correlated with Immune Infiltrates in Lower-Grade Glioma. Journal of Oncology, 2022.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

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