FPR1

This gene encodes a G protein-coupled receptor of mammalian phagocytic cells that is a member of the G-protein coupled receptor 1 family. The protein mediates the response of phagocytic cells to invasion of the host by microorganisms and is important in host defense and inflammation.[provided by RefSeq, Jul 2010]

Formyl Peptide Receptor 1

High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors (PubMed:2161213, PubMed:2176894, PubMed:10514456, PubMed:15153520).

Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release (PubMed:2161213, PubMed:1712023, PubMed:15153520).

This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:1712023, PubMed:10514456).

Receptor for TAFA4, mediates its effects on chemoattracting macrophages, promoting phagocytosis and increasing ROS release (PubMed:25109685).

Activation of MAPK activity Source: ProtInc
Adenylate cyclase-modulating G protein-coupled receptor signaling pathway Source: ProtInc
Chemotaxis Source: ProtInc
Complement receptor mediated signaling pathway Source: GO_Central
G protein-coupled receptor signaling pathway Source: ProtInc
Inflammatory response Source: GO_Central
Nitric oxide mediated signal transduction Source: ProtInc
Phospholipase C-activating G protein-coupled receptor signaling pathway Source: MGI
Positive regulation of cytosolic calcium ion concentration Source: GO_Central
Signal transduction Source: ProtInc

Cell membrane. Internalizes in presence of its ligand, TAFA4.

Extracellular: 1-27
Helical: 28-50
Cytoplasmic: 51-61
Helical: 62-83
Extracellular: 84-100
Helical: 101-121
Cytoplasmic: 122-140
Helical: 141-162
Extracellular: 163-205
Helical: 206-226
Cytoplasmic: 227-242
Helical: 243-266
Extracellular: 267-285
Helical: 286-305
Cytoplasmic: 306-350

Phosphorylated; which is necessary for desensitization.