FPR1

This gene encodes a G protein-coupled receptor of mammalian phagocytic cells that is a member of the G-protein coupled receptor 1 family. The protein mediates the response of phagocytic cells to invasion of the host by microorganisms and is important in host defense and inflammation.[provided by RefSeq, Jul 2010]
Full Name
Formyl Peptide Receptor 1
Function
High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors (PubMed:2161213, PubMed:2176894, PubMed:10514456, PubMed:15153520).

Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release (PubMed:2161213, PubMed:1712023, PubMed:15153520).

This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:1712023, PubMed:10514456).

Receptor for TAFA4, mediates its effects on chemoattracting macrophages, promoting phagocytosis and increasing ROS release (PubMed:25109685).
Biological Process
Activation of MAPK activity Source: ProtInc
Adenylate cyclase-modulating G protein-coupled receptor signaling pathway Source: ProtInc
Chemotaxis Source: ProtInc
Complement receptor mediated signaling pathway Source: GO_Central
G protein-coupled receptor signaling pathway Source: ProtInc
Inflammatory response Source: GO_Central
Nitric oxide mediated signal transduction Source: ProtInc
Phospholipase C-activating G protein-coupled receptor signaling pathway Source: MGI
Positive regulation of cytosolic calcium ion concentration Source: GO_Central
Signal transduction Source: ProtInc
Cellular Location
Cell membrane. Internalizes in presence of its ligand, TAFA4.
Topology
Extracellular: 1-27
Helical: 28-50
Cytoplasmic: 51-61
Helical: 62-83
Extracellular: 84-100
Helical: 101-121
Cytoplasmic: 122-140
Helical: 141-162
Extracellular: 163-205
Helical: 206-226
Cytoplasmic: 227-242
Helical: 243-266
Extracellular: 267-285
Helical: 286-305
Cytoplasmic: 306-350
PTM
Phosphorylated; which is necessary for desensitization.
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Anti-FPR1 antibodies

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Mouse Anti-FPR1 Recombinant Antibody (F1979) (V2LY-1225-LY74)

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Target: FPR1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: F1979
Application*: WB, IF
Datasheet SDS

Mouse Anti-FPR1 Recombinant Antibody (CBXF-1979) (V2LY-1225-LY73)

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Target: FPR1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-1979
Application*: WB, IF
Datasheet SDS

Mouse Anti-FPR1 Recombinant Antibody (CBXF-2667) (V2LY-1225-LY71)

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Target: FPR1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXF-2667
Application*: F
Datasheet SDS

Rabbit Anti-FPR1 Recombinant Antibody (EG1241) (CBMAB-EN1499-LY)

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Target: FPR1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: EG1241
Application*: WB: 1:500~1:1000 IF: 1:100~1:500 ELISA: 1:1000
Datasheet SDS

Mouse Anti-FPR1 Recombinant Antibody (NFPRb) (CBMAB-F1979-CQ)

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Target: FPR1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: NFPRb
Application*: WB, IF, IP
Datasheet SDS

Mouse Anti-FPR1 Recombinant Antibody (CBXF-1979) (CBMAB-F0611-CQ)

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Target: FPR1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXF-1979
Application*: F
Datasheet SDS

Human Anti-FPR1 Recombinant Antibody (CBXF-1284) (CBMAB-F0239-CQ)

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Target: FPR1
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-1284
Application*: F
Datasheet SDS

Mouse Anti-FPR1 Recombinant Antibody (CBXF-2667) (CBMAB-F0149-CQ)

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Target: FPR1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXF-2667
Application*: F
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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