Search :
Sign in or Register  
Welcome Sign in or Don't have an account?Register

Rabbit Anti-FPR1 Recombinant Antibody (EG1241) (CBMAB-EN1499-LY)


See all FPR1 antibodies
Online Inquiry

Summary

Host Animal
Rabbit
Specificity
Human
Clone
EG1241
Antibody Isotype
IgG
Application
WB: 1:500~1:1000 IF: 1:100~1:500 ELISA: 1:1000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from internal of human FPR1.
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Formyl Peptide Receptor 1
Introduction
This gene encodes a G protein-coupled receptor of mammalian phagocytic cells that is a member of the G-protein coupled receptor 1 family. The protein mediates the response of phagocytic cells to invasion of the host by microorganisms and is important in host defense and inflammation.[provided by RefSeq, Jul 2010]
Entrez Gene ID
2357
UniProt ID
P21462
Alternative Names
Formyl Peptide Receptor 1; N-Formylpeptide Chemoattractant Receptor; FMLP Receptor; FPR; N-Formyl Peptide Receptor; FMet-Leu-Phe Receptor; FMLP;
Function
High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors (PubMed:2161213, PubMed:2176894, PubMed:10514456, PubMed:15153520).

Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release (PubMed:2161213, PubMed:1712023, PubMed:15153520).

This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:1712023, PubMed:10514456).

Receptor for TAFA4, mediates its effects on chemoattracting macrophages, promoting phagocytosis and increasing ROS release (PubMed:25109685).
Biological Process
Activation of MAPK activity Source: ProtInc
Adenylate cyclase-modulating G protein-coupled receptor signaling pathway Source: ProtInc
Chemotaxis Source: ProtInc
Complement receptor mediated signaling pathway Source: GO_Central
G protein-coupled receptor signaling pathway Source: ProtInc
Inflammatory response Source: GO_Central
Nitric oxide mediated signal transduction Source: ProtInc
Phospholipase C-activating G protein-coupled receptor signaling pathway Source: MGI
Positive regulation of cytosolic calcium ion concentration Source: GO_Central
Signal transduction Source: ProtInc
Cellular Location
Cell membrane. Internalizes in presence of its ligand, TAFA4.
Topology
Extracellular: 1-27
Helical: 28-50
Cytoplasmic: 51-61
Helical: 62-83
Extracellular: 84-100
Helical: 101-121
Cytoplasmic: 122-140
Helical: 141-162
Extracellular: 163-205
Helical: 206-226
Cytoplasmic: 227-242
Helical: 243-266
Extracellular: 267-285
Helical: 286-305
Cytoplasmic: 306-350
PTM
Phosphorylated; which is necessary for desensitization.
More Infomation

Zhuang, Y., Wang, L., Guo, J., Sun, D., Wang, Y., Liu, W., ... & Zhang, C. (2022). Molecular recognition of formylpeptides and diverse agonists by the formylpeptide receptors FPR1 and FPR2. Nature communications, 13(1), 1054.

Vecchi, L., Mota, S. T. S., Zóia, M. A. P., Martins, I. C., de Souza, J. B., Santos, T. G., ... & Araújo, T. G. (2022). Interleukin-6 Signaling in Triple Negative Breast Cancer Cells Elicits the Annexin A1/Formyl Peptide Receptor 1 Axis and Affects the Tumor Microenvironment. Cells, 11(10), 1705.

Liotti, F., Marotta, M., Sorriento, D., Pagliuca, C., Caturano, V., Mantova, G., ... & Prevete, N. (2022). Probiotic Lactobacillus rhamnosus GG (LGG) restrains the angiogenic potential of colorectal carcinoma cells by activating a proresolving program via formyl peptide receptor 1. Molecular Oncology, 16(16), 2959-2980.

Korinek, M., Hsieh, P. S., Chen, Y. L., Hsieh, P. W., Chang, S. H., Wu, Y. H., & Hwang, T. L. (2021). Randialic acid B and tomentosolic acid block formyl peptide receptor 1 in human neutrophils and attenuate psoriasis-like inflammation in vivo. Biochemical Pharmacology, 190, 114596.

Chiang, S. F., Huang, K. C. Y., Chen, W. T. L., Chen, T. W., Ke, T. W., & Chao, K. C. (2021). Polymorphism of formyl peptide receptor 1 (FPR1) reduces the therapeutic efficiency and antitumor immunity after neoadjuvant chemoradiotherapy (CCRT) treatment in locally advanced rectal cancer. Cancer Immunology, Immunotherapy, 70(10), 2937-2950.

Li, Z., Li, Y., Han, J., Zhu, Z., Li, M., Liu, Q., ... & Shi, F. D. (2021). Formyl peptide receptor 1 signaling potentiates inflammatory brain injury. Science translational medicine, 13(605), eabe9890.

Fusco, R., Gugliandolo, E., Siracusa, R., Scuto, M., Cordaro, M., D’Amico, R., ... & Di Paola, R. (2020). Formyl peptide receptor 1 signaling in acute inflammation and neural differentiation induced by traumatic brain injury. Biology, 9(9), 238.

Nishiguchi, T., Yoshimura, H., Kasai, R. S., Fujiwara, T. K., & Ozawa, T. (2020). Synergetic roles of formyl peptide receptor 1 oligomerization in ligand-induced signal transduction. ACS Chemical Biology, 15(9), 2577-2587.

Li, S. Q., Yu, Y., Zhang, Y., Sun, Y. P., Li, X. X., & Su, N. (2020). The role of formyl peptide receptor 1 gene polymorphisms in human colorectal cancer. Journal of Cancer, 11(12), 3580.

Fusco, R., D’amico, R., Cordaro, M., Gugliandolo, E., Siracusa, R., Peritore, A. F., ... & Di Paola, R. (2018). Absence of formyl peptide receptor 1 causes endometriotic lesion regression in a mouse model of surgically-induced endometriosis. Oncotarget, 9(59), 31355.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Rabbit Anti-FPR1 Recombinant Antibody (EG1241)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Request bulk or custom quote
Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Online Inquiry