FZD2

This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the wingless type MMTV integration site family of signaling proteins. This gene encodes a protein that is coupled to the beta-catenin canonical signaling pathway. Competition between the wingless-type MMTV integration site family, member 3A and wingless-type MMTV integration site family, member 5A gene products for binding of this protein is thought to regulate the beta-catenin-dependent and -independent pathways.

frizzled class receptor 2

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (PubMed:25759469).

A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

(Microbial infection) Acts as a receptor for C.difficile toxin TcdB in the colonic epithelium (PubMed:27680706, PubMed:29748286).

TcdB occupies the binding site for Wnt-adducted palmitoleate in frizzled receptors and TcdB-binding prevents Wnt-binding and downstream Wnt signaling (PubMed:29748286).

Canonical Wnt signaling pathway Source: UniProtKB
Cochlea morphogenesis Source: Ensembl
Epithelial cell differentiation Source: Ensembl
Hard palate development Source: Ensembl
Inner ear receptor cell development Source: Ensembl
Membranous septum morphogenesis Source: Ensembl
Muscular septum morphogenesis Source: Ensembl
Neuron differentiation Source: UniProtKB
Outflow tract morphogenesis Source: Ensembl
Planar cell polarity pathway involved in neural tube closure Source: Ensembl
Positive regulation of DNA-binding transcription factor activity Source: BHF-UCL
Positive regulation of transcription, DNA-templated Source: BHF-UCL
Sensory perception of smell Source: Ensembl
Wnt signaling pathway Source: UniProtKB
Wnt signaling pathway, planar cell polarity pathway Source: ParkinsonsUK-UCL

Cell membrane; Membrane

Omodysplasia 2 (OMOD2):
A rare autosomal dominant skeletal dysplasia characterized by short humeri, radial head dislocation, short first metacarpals, facial dysmorphism and genitourinary anomalies.
Defects in FZD2 have been found in patients with Robinow syndrome-like features including short-limb dwarfism, broad thumbs and craniofacial abnormalities.

Extracellular: 24-247
Helical: 248-268
Cytoplasmic: 269-279
Helical: 280-300
Extracellular: 301-327
Helical: 328-348
Cytoplasmic: 349-370
Helical: 371-391
Extracellular: 392-414
Helical: 415-435
Cytoplasmic: 436-461
Helical: 462-482
Extracellular: 483-519
Helical: 520-540
Cytoplasmic: 541-565

Ubiquitinated by ZNRF3, leading to its degradation by the proteasome.