GITR

Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1.

tumor necrosis factor receptor superfamily, member 18

Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway.

Apoptotic process Source: UniProtKB-KW
Negative regulation of apoptotic process Source: ProtInc
Positive regulation of cell adhesion Source: UniProtKB
Positive regulation of leukocyte migration Source: UniProtKB
Positive regulation of tyrosine phosphorylation of STAT protein Source: UniProtKB
Signal transduction Source: ProtInc

Isoform 1: Cell membrane
Isoform 2: Secreted

Extracellular: 26-162
Helical: 163-183
Cytoplasmic: 184-241