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Rat Anti-GITR Recombinant Antibody (DTA-1) (CBMAB-1017-LY)

This product is rat antibody recognizes mouse GITR. The antibody DTA-1 immunoassay techniques such as: Stimulation.
See all GITR antibodies
Published Data
Fig.1 Flow cytometric analysis of the indicated Treg cell markers expressed on CD4 T cells from the spleens of BXD2-IL-21/ mice and wild-type BXD2 mice.
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Summary

Host Animal
Rat
Specificity
Mouse
Clone
DTA-1
Antibody Isotype
IgG2b

Basic Information

Specificity
Mouse
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
tumor necrosis factor receptor superfamily, member 18
Introduction
Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1.
Entrez Gene ID
21936
UniProt ID
Q7TS55
Alternative Names
AITR; Gitr; Tnfrsf18
Function
Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway.
Biological Process
Apoptotic process Source: UniProtKB-KW
Negative regulation of apoptotic process Source: ProtInc
Positive regulation of cell adhesion Source: UniProtKB
Positive regulation of leukocyte migration Source: UniProtKB
Positive regulation of tyrosine phosphorylation of STAT protein Source: UniProtKB
Signal transduction Source: ProtInc
Cellular Location
Isoform 1: Cell membrane
Isoform 2: Secreted
Topology
Extracellular: 26-162
Helical: 163-183
Cytoplasmic: 184-241
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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