GPR101

The protein encoded by this gene is an orphan G protein-coupled receptor of unknown function. The encoded protein is a member of a family of proteins that contain seven transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. [provided by RefSeq, Sep 2011]

Full Name

G Protein-Coupled Receptor 101

Function

Orphan receptor.

Biological Process

Adenylate cyclase-activating adrenergic receptor signaling pathway Source: GO_Central

Cellular Location

Cell membrane

Involvement in disease

Pituitary adenoma 2, growth hormone-secreting (PITA2):
A form of pituitary adenoma, a neoplasm of the pituitary gland and one of the most common neuroendocrine tumors. Pituitary adenomas are clinically classified as functional and non-functional tumors, and manifest with a variety of features, including local invasion of surrounding structures and excessive hormone secretion. Functional pituitary adenomas are further classified by the type of hormone they secrete. PITA2 is a growth hormone-secreting benign neoplasm, also known as somatotropinoma. It clinically results in acromegaly, a condition characterized by coarse facial features, protruding jaw, and enlarged extremities. Excessive production of growth hormone in children or adolescents before the closure of epiphyses causes gigantism, a condition characterized by abnormally tall stature.

Topology

Extracellular: 1-35
Helical: 36-56
Cytoplasmic: 57-68
Helical: 69-89
Extracellular: 90-106
Helical: 107-127
Cytoplasmic: 128-149
Helical: 150-170
Extracellular: 171-196
Helical: 197-217
Cytoplasmic: 218-399
Helical: 400-420
Extracellular: 421-433
Helical: 434-454
Cytoplasmic: 455-508