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Rabbit Anti-GPR101 Recombinant Antibody (EG1355) (CBMAB-EN1634-LY)


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Summary

Host Animal
Rabbit
Specificity
Human
Clone
EG1355
Antibody Isotype
IgG
Application
IF: 1:100~1:500 ELISA: 1:5000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from internal of human GPR101.
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
G Protein-Coupled Receptor 101
Introduction
The protein encoded by this gene is an orphan G protein-coupled receptor of unknown function. The encoded protein is a member of a family of proteins that contain seven transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. [provided by RefSeq, Sep 2011]
Entrez Gene ID
83550
UniProt ID
Q96P66
Alternative Names
G Protein-Coupled Receptor 101; Probable G-Protein Coupled Receptor 101; GPCR6; PAGH2; PITA2;
Function
Orphan receptor.
Biological Process
Adenylate cyclase-activating adrenergic receptor signaling pathway Source: GO_Central
Cellular Location
Cell membrane
Involvement in disease
Pituitary adenoma 2, growth hormone-secreting (PITA2):
A form of pituitary adenoma, a neoplasm of the pituitary gland and one of the most common neuroendocrine tumors. Pituitary adenomas are clinically classified as functional and non-functional tumors, and manifest with a variety of features, including local invasion of surrounding structures and excessive hormone secretion. Functional pituitary adenomas are further classified by the type of hormone they secrete. PITA2 is a growth hormone-secreting benign neoplasm, also known as somatotropinoma. It clinically results in acromegaly, a condition characterized by coarse facial features, protruding jaw, and enlarged extremities. Excessive production of growth hormone in children or adolescents before the closure of epiphyses causes gigantism, a condition characterized by abnormally tall stature.
Topology
Extracellular: 1-35
Helical: 36-56
Cytoplasmic: 57-68
Helical: 69-89
Extracellular: 90-106
Helical: 107-127
Cytoplasmic: 128-149
Helical: 150-170
Extracellular: 171-196
Helical: 197-217
Cytoplasmic: 218-399
Helical: 400-420
Extracellular: 421-433
Helical: 434-454
Cytoplasmic: 455-508
More Infomation

Flak, M. B., Koenis, D. S., Gonzalez-Nunez, M., Chopo-Pizarro, A., & Dalli, J. (2023). Deletion of macrophage Gpr101 disrupts their phenotype and function dysregulating host immune responses in sterile and infectious inflammation. Biochemical Pharmacology, 207, 115348.

Franke, M., Daly, A. F., Palmeira, L., Tirosh, A., Stigliano, A., Trifan, E., ... & Trivellin, G. (2022). Duplications disrupt chromatin architecture and rewire GPR101-enhancer communication in X-linked acrogigantism. The American Journal of Human Genetics, 109(4), 553-570.

Bao, X. D., Lu, L., Zhu, H. J., Yao, Y., Feng, M., Wang, R. Z., ... & Lu, Z. L. (2022). Concurrent mutations of germline GPR101 and somatic USP8 in a pediatric giant pituitary ACTH adenoma: a case report. BMC Endocrine Disorders, 22(1), 152.

Elizabeth, M. S., Verkerk, A. J., Hokken-Koelega, A. C., Verlouw, J. A., Argente, J., Pfaeffle, R., ... & de Graaff, L. C. (2021). Congenital hypopituitarism in two brothers with a duplication of the ‘acrogigantism gene’GPR101: clinical findings and review of the literature. Pituitary, 24, 229-241.

Trivellin, G., Tirosh, A., Hernández-Ramírez, L. C., Gupta, T., Tsai-Morris, C. H., Faucz, F. R., ... & Stratakis, C. A. (2021). The X-linked acrogigantism-associated gene gpr101 is a regulator of early embryonic development and growth in zebrafish. Molecular and cellular endocrinology, 520, 111091.

Trivellin, G., Faucz, F. R., Daly, A. F., Beckers, A., & Stratakis, C. A. (2020). Hereditary endocrine tumours: current state-of-the-art and research opportunities: GPR101, an orphan GPCR with roles in growth and pituitary tumorigenesis. Endocrine-Related Cancer, 27(8), T87-T97.

Flak, M. B., Koenis, D. S., Sobrino, A., Smith, J., Pistorius, K., Palmas, F., & Dalli, J. (2020). GPR101 mediates the pro-resolving actions of RvD5 n-3 DPA in arthritis and infections. The Journal of clinical investigation, 130(1), 359-373.

Abboud, D., Daly, A. F., Dupuis, N., Bahri, M. A., Inoue, A., Chevigné, A., ... & Hanson, J. (2020). GPR101 drives growth hormone hypersecretion and gigantism in mice via constitutive activation of Gs and Gq/11. Nature communications, 11(1), 4752.

Vasilev, V., Daly, A. F., Trivellin, G., Stratakis, C. A., Zacharieva, S., & Beckers, A. (2020). Hereditary endocrine tumours: Current state-of-the-art and research opportunities: The roles of AIP and GPR101 in familial isolated pituitary adenomas (FIPA). Endocrine-Related Cancer, 27(8), T77-T86.

Hou, Z. S., & Tao, Y. X. (2019). Mutations in GPR101 as a potential cause of X-linked acrogigantism and acromegaly. Progress in Molecular Biology and Translational Science, 161, 47-67.

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For research use only. Not intended for any clinical use.

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