GPR139

This gene encodes a member of the rhodopsin family of G-protein-coupled receptors. The encoded protein is almost exclusively expressed in the central nervous system. L-tryptophan and L-phenylalanine may act as the physiologic ligands of the encoded protein. Alternative splicing results in multiple transcript variants.

Full Name

G protein-coupled receptor 139

Function

Orphan receptor. Seems to act through a G(q/11)-mediated pathway.

Biological Process

G protein-coupled receptor signaling pathway Source: MGI
Phospholipase C-activating G protein-coupled receptor signaling pathway Source: Ensembl

Cellular Location

Cell membrane

Topology

Extracellular: 1-29
Helical: 30-50
Cytoplasmic: 51-65
Helical: 66-86
Extracellular: 87-102
Helical: 103-123
Cytoplasmic: 124-148
Helical: 149-169
Extracellular: 170-181
Helical: 182-202
Cytoplasmic: 203-228
Helical: 229-249
Extracellular: 250-268
Helical: 269-289
Cytoplasmic: 290-353

Anti-GPR139 antibodies

Rabbit Anti-GPR139 Recombinant Antibody (EG1376) (CBMAB-EN1655-LY)

Datasheet

SDS

Target: GPR139

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: EG1376

Application*: IF: 1:100~1:500 ELISA: 1:1000

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)