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Rabbit Anti-GPR139 Recombinant Antibody (EG1376) (CBMAB-EN1655-LY)

The product is antibody recognizes GPR139. The antibody EG1376 immunoassay techniques such as: IF: 1:100~1:500 ELISA: 1:1000.
See all GPR139 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
EG1376
Antibody Isotype
IgG
Application
IF: 1:100~1:500 ELISA: 1:1000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from internal of human GPR139.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
G protein-coupled receptor 139
Introduction
This gene encodes a member of the rhodopsin family of G-protein-coupled receptors. The encoded protein is almost exclusively expressed in the central nervous system. L-tryptophan and L-phenylalanine may act as the physiologic ligands of the encoded protein. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
Human124274
Mouse209776
Rat293545
UniProt ID
HumanQ6DWJ6
MouseQ80UC8
RatP0C0W8
Alternative Names
PGR3; GPRg1
Function
Orphan receptor. Seems to act through a G(q/11)-mediated pathway.
Biological Process
G protein-coupled receptor signaling pathway Source: MGI
Phospholipase C-activating G protein-coupled receptor signaling pathway Source: Ensembl
Cellular Location
Cell membrane
Topology
Extracellular: 1-29
Helical: 30-50
Cytoplasmic: 51-65
Helical: 66-86
Extracellular: 87-102
Helical: 103-123
Cytoplasmic: 124-148
Helical: 149-169
Extracellular: 170-181
Helical: 182-202
Cytoplasmic: 203-228
Helical: 229-249
Extracellular: 250-268
Helical: 269-289
Cytoplasmic: 290-353

Pallareti, L., Rath, T. F., Trapkov, B., Tsonkov, T., Nielsen, A. T., Harpsøe, K., ... & Foster, S. R. (2023). Pharmacological characterization of novel small molecule agonists and antagonists for the orphan receptor GPR139. European Journal of Pharmacology, 943, 175553.

Roy, N., Ogawa, S., Maniam, R., & Parhar, I. (2021). Habenula GPR139 is associated with fear learning in the zebrafish. Scientific Reports, 11(1), 1-14.

Kamel, A., Bowlin, S., Hosea, N., Arkilo, D., & Laurenza, A. (2021). In Vitro Metabolism of Slowly Cleared G Protein–Coupled Receptor 139 Agonist TAK-041 Using Rat, Dog, Monkey, and Human Hepatocyte Models (HepatoPac): Correlation with In Vivo Metabolism. Drug Metabolism and Disposition, 49(2), 121-132.

Kaushik, A. C., Mehmood, A., Dai, X., & Wei, D. Q. (2021). Pan-cancer Analysis and Drug Formulation for GPR139 and GPR142. Frontiers in Pharmacology, 11, 521245.

Vedel, L., Nøhr, A. C., Gloriam, D. E., & Bräuner‐Osborne, H. (2020). Pharmacology and function of the orphan GPR139 G protein‐coupled receptor. Basic & Clinical Pharmacology & Toxicology, 126, 35-46.

Stoveken, H. M., Zucca, S., Masuho, I., Grill, B., & Martemyanov, K. A. (2020). The orphan receptor GPR139 signals via Gq/11 to oppose opioid effects. Journal of Biological Chemistry, 295(31), 10822-10830.

Laschet, C., Dupuis, N., & Hanson, J. (2018). The G protein-coupled receptors deorphanization landscape. Biochemical Pharmacology, 153, 62-74.

Alavi, M. S., Shamsizadeh, A., Azhdari-Zarmehri, H., & Roohbakhsh, A. (2018). Orphan G protein-coupled receptors: The role in CNS disorders. Biomedicine & Pharmacotherapy, 98, 222-232.

Kononoff, J., Kallupi, M., Kimbrough, A., Conlisk, D., de Guglielmo, G., & George, O. (2018). Systemic and intra-habenular activation of the orphan G protein-coupled receptor GPR139 decreases compulsive-like alcohol drinking and hyperalgesia in alcohol-dependent rats. Eneuro, 5(3).

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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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