GPR153

This gene encodes an integral membrane protein that belongs to the Class A rhodopsin superfamily of G protein coupled receptors. The encoded protein is expressed primarily in the central nervous system. A knockdown of the orthologous gene in rat is associated with a significant reduction in food intake and impaired decision making ability. Mutations in this gene are associated with schizophrenia, autism, and other neuropsychiatric disorders. The expression of this gene is activated by the glioma-associated oncogene homolog 1 transcription factor which, in turn, is activated by sonic hedgehog in normal and tumorigenic cells.

G protein-coupled receptor 153

Orphan receptor.

Cell membrane

Extracellular: 1-11
Helical: 12-32
Cytoplasmic: 33-41
Helical: 42-62
Extracellular: 63-84
Helical: 85-105
Cytoplasmic: 106-126
Helical: 127-147
Extracellular: 148-175
Helical: 176-196
Cytoplasmic: 197-243
Helical: 244-264
Extracellular: 265-276
Helical: 277-297
Cytoplasmic: 298-609