GRM3

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.

GLUTAMATE METABOTROPIC RECEPTOR 3

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.

Chemical synaptic transmission Source: ProtInc
Gene expression Source: Ensembl
G protein-coupled glutamate receptor signaling pathway Source: GO_Central
Negative regulation of adenylate cyclase activity Source: ProtInc
Regulation of synaptic transmission, glutamatergic Source: GO_Central

Cell membrane

Extracellular: 23-576
Helical: 577-599
Cytoplasmic: 600-613
Helical: 614-634
Extracellular: 635-645
Helical: 646-664
Cytoplasmic: 665-688
Helical: 689-709
Extracellular: 710-734
Helical: 735-756
Cytoplasmic: 757-769
Helical: 770-792
Extracellular: 793-802
Helical: 803-828
Cytoplasmic: 829-879