Mouse Anti-GRM3 Recombinant Antibody (CBT2197) (V2LY-0625-LY749)

Name: Mouse Anti-GRM3 Recombinant Antibody (CBT2197)
SKU: V2LY-0625-LY749
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBT2197

Antibody Isotype

IgG2a

Application

IHC, ICC, FC

Basic Information

Immunogen

Purified recombinant fragment of human GRM3 (AA: extra 433-576) expressed in E. Coli.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2a

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:500-1:2,000
IHC-P	1:200-1:1,000
ICC	1:200-1:1,000
FC	1:200-1:400
ELISA	1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

Sodium azide

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

GLUTAMATE METABOTROPIC RECEPTOR 3

Entrez Gene ID

2913

UniProt ID

Q14832

Function

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.

Biological Process

Chemical synaptic transmission Source: ProtInc
Gene expression Source: Ensembl
G protein-coupled glutamate receptor signaling pathway Source: GO_Central
Negative regulation of adenylate cyclase activity Source: ProtInc
Regulation of synaptic transmission, glutamatergic Source: GO_Central

Cellular Location

Cell membrane

Topology

Extracellular: 23-576
Helical: 577-599
Cytoplasmic: 600-613
Helical: 614-634
Extracellular: 635-645
Helical: 646-664
Cytoplasmic: 665-688
Helical: 689-709
Extracellular: 710-734
Helical: 735-756
Cytoplasmic: 757-769
Helical: 770-792
Extracellular: 793-802
Helical: 803-828
Cytoplasmic: 829-879

More Infomation

References

Woo, E., Datta, D., & Arnsten, A. F. (2022). Glutamate metabotropic receptor type 3 (mGlu3) localization in the rat prelimbic medial prefrontal cortex. Frontiers in Neuroanatomy, 23.

Wirsching, H. G., Silginer, M., Ventura, E., Macnair, W., Burghardt, I., Claassen, M., ... & Weller, M. (2021). Negative allosteric modulators of metabotropic glutamate receptor 3 target the stem-like phenotype of glioblastoma. Molecular Therapy-Oncolytics, 20, 166-174.

Li, J., Yu, Y., Zhao, J., Zhang, J., Wang, Y., Ding, K., ... & Zhang, K. (2021). Genetic variants of the type-3 metabotropic glutamate receptor gene associated with human spatial localization ability. Gene Reports, 23, 101135.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Related Products

Mouse Anti-GRM3 Recombinant Antibody (CBT4741)

Rabbit Anti-GRM3 Recombinant Antibody (CBLG1-1793)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
Request for COA

Request bulk or custom quote
Second antibody and isotype control

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