IFNLR1

IFNLR1 belongs to the class II cytokine receptor family. This protein forms a receptor complex with interleukine 10 receptor, beta (IL10RB). The receptor complex has been shown to interact with three closely related cytokines, including interleukin 28A (IL28A), interleukin 28B (IL28B), and interleukin 29 (IL29). The expression of all three cytokines can be induced by viral infection. The cells overexpressing this protein have been found to have enhanced responses to IL28A and IL29, but decreased response to IL28B.

Full Name

Interferon Lambda Receptor 1

Function

The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, and reproductive tracts. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium.

Biological Process

Cytokine-mediated signaling pathway Source: GO_Central
Defense response to virus Source: UniProtKB
Mucosal immune response Source: UniProtKB
Negative regulation of cell population proliferation Source: UniProtKB
Positive regulation of cellular respiration Source: ARUK-UCL
Regulation of defense response to virus by host Source: UniProtKB
Response to type III interferon Source: UniProtKB

Cellular Location

Membrane

Topology

Extracellular: 21-228
Helical: 229-249
Cytoplasmic: 250-520