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Mouse Anti-IFNLR1 Recombinant Antibody (CBYY-I0331) (CBMAB-I0868-YY)

This product is Mouse antibody that recognizes IFNLR1. The antibody CBYY-I0331 can be used for immunoassay techniques such as: FC
See all IFNLR1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYY-I0331
Antibody Isotype
IgG2a, κ
Application
FC

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2, 0.2% (w/v) BSA
Preservative
0.09% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Interferon Lambda Receptor 1
Introduction
The protein encoded by this gene belongs to the class II cytokine receptor family. This protein forms a receptor complex with interleukine 10 receptor, beta (IL10RB). The receptor complex has been shown to interact with three closely related cytokines, including interleukin 28A (IL28A), interleukin 28B (IL28B), and interleukin 29 (IL29). The expression of all three cytokines can be induced by viral infection.
Entrez Gene ID
163702
UniProt ID
Q8IU57
Alternative Names
CRF2/12, IFNLR, IL-28R1, IL28RA, LICR2
Function
The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, and reproductive tracts. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium.
Biological Process
Cytokine-mediated signaling pathway Source: GO_Central
Defense response to virus Source: UniProtKB
Mucosal immune response Source: UniProtKB
Negative regulation of cell population proliferation Source: UniProtKB
Positive regulation of cellular respiration Source: ARUK-UCL
Regulation of defense response to virus by host Source: UniProtKB
Response to type III interferon Source: UniProtKB
Cellular Location
Membrane
Topology
Extracellular: 21-228
Helical: 229-249
Cytoplasmic: 250-520

Evans, J. G., Novotny, L. A., & Meissner, E. G. (2023). Influence of Canonical and Non-Canonical IFNLR1 Isoform Expression on Interferon Lambda Signaling. Viruses, 15(3), 632.

Zhang, T. Y., Chen, T., Hu, W. Y., Li, J. C., & Guo, M. Y. (2022). Ammonia induces autophagy via circ‐IFNLR1/miR‐2188‐5p/RNF182 axis in tracheas of chickens. Biofactors, 48(2), 416-427.

Wang, W. Q., Qiu, S. W., Huang, S. S., Wang, G. J., Han, M. Y., Kang, D. Y., ... & Dai, P. (2022). Transcriptome analysis of the early stage ifnlr1-mutant zebrafish indicates the immune response to auditory dysfunction. Gene Expression Patterns, 43, 119229.

Qin, M., Chen, W., Li, Z., Wang, L., Ma, L., Geng, J., ... & Zeng, Y. (2021). Role of IFNLR1 gene in PRRSV infection of PAM cells. Journal of Veterinary Science, 22(3).

Hausmann, L. D., de Almeida, B. S., de Souza, I. R., Drehmer, M. N., Fernandes, B. L., Wilkens, R. S., ... & Muniz, Y. C. N. (2021). Association of TNFRSF1A and IFNLR1 gene polymorphisms with the risk of developing breast cancer and clinical pathologic features. Biochemical Genetics, 59, 1233-1246.

Evans, G., Kappler, C. S., Liu, R., Carten, J. D., Orr, C. M., Stephenson, S., ... & Meissner, E. G. (2021). 49483 Evaluating the Role of IFNLR1 Receptor Dynamics and Plasticity in Regulating Cellular Response to Interferons. Journal of Clinical and Translational Science, 5(s1), 14-15.

Zhang, A. M., Wang, Y., Xia, X., & Song, Y. (2020). Genetic polymorphisms of the IFNLR1 gene correlate with HCV infection and biochemical features of chronic HCV patients in Yunnan, China. Immunological Investigations, 49(4), 453-461.

Ma, N., Zhang, X., Yang, L., Zhou, J., Liu, W., Gao, X., ... & Liu, D. (2018). Role of Functional IFNL 4, IFNLR 1, IFNA, IFNAR 2 Polymorphisms in Hepatitis B virus‐related liver disease in Han Chinese population. Journal of viral hepatitis, 25(3), 306-313.

Gao, X., Yuan, Y. Y., Lin, Q. F., Xu, J. C., Wang, W. Q., Qiao, Y. H., ... & Dai, P. (2018). Mutation of IFNLR1, an interferon lambda receptor 1, is associated with autosomal-dominant non-syndromic hearing loss. Journal of medical genetics, 55(5), 298-306.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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