IL10RB
The protein encoded by this gene belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10-induced signal transduction. This gene and three other interferon receptor genes, IFAR2, IFNAR1, and IFNGR2, form a class II cytokine receptor gene cluster located in a small region on chromosome 21.
Full Name
interleukin 10 receptor, beta
Function
Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state.
Biological Process
Cytokine-mediated signaling pathway Source: GO_Central
Defense response to virus Source: UniProtKB-KW
Immune response Source: ProtInc
Inflammatory response Source: ProtInc
Positive regulation of cellular respiration Source: ARUK-UCL
Positive regulation of receptor signaling pathway via JAK-STAT Source: UniProtKB
Signal transduction Source: ProtInc
Cellular Location
Membrane
Involvement in disease
Inflammatory bowel disease 25, autosomal recessive (IBD25):
A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints.
Topology
Extracellular: 20-220
Helical: 221-242
Cytoplasmic: 243-325
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Datasheet