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Mouse Anti-IL10RB Recombinant Antibody (90220) (CBMAB-I1788-YY)

This product is Mouse antibody that recognizes IL10RB. The antibody 90220 can be used for immunoassay techniques such as: WB, FC, Neut, CyTOF
See all IL10RB antibodies
Published Data

Summary

Host Animal
Mouse
Specificity
Human
Clone
90220
Antibody Isotype
IgG1
Application
WB, FC, Neut, CyTOF

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
0.2 μm filtered solution in with Trehalose
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
interleukin 10 receptor, beta
Introduction
The protein encoded by this gene belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10-induced signal transduction. This gene and three other interferon receptor genes, IFAR2, IFNAR1, and IFNGR2, form a class II cytokine receptor gene cluster located in a small region on chromosome 21.
Entrez Gene ID
UniProt ID
Alternative Names
Interleukin 10 Receptor Subunit Beta
Function
Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state.
Biological Process
Cytokine-mediated signaling pathway Source: GO_Central
Defense response to virus Source: UniProtKB-KW
Immune response Source: ProtInc
Inflammatory response Source: ProtInc
Positive regulation of cellular respiration Source: ARUK-UCL
Positive regulation of receptor signaling pathway via JAK-STAT Source: UniProtKB
Signal transduction Source: ProtInc
Cellular Location
Membrane
Involvement in disease
Inflammatory bowel disease 25, autosomal recessive (IBD25):
A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints.
Topology
Extracellular: 20-220
Helical: 221-242
Cytoplasmic: 243-325

Grk, M., Miskovic, R., Jeremic, I., Basaric, M., Dusanovic Pjevic, M., Jekic, B., ... & Banko, A. (2023). Association of IL10RA, IL10RB, and IL22RA Polymorphisms/Haplotypes with Susceptibility to and Clinical Manifestations of SLE. International Journal of Molecular Sciences, 24(14), 11292.

Mao, Z., Betti, M. J., Cedeno, M. A., Pedroza, L. A., Basaria, S., Liu, Q., ... & Markle, J. G. (2023). Clinical and cellular phenotypes resulting from a founder mutation in IL10RB. Clinical and Experimental Immunology, uxad085.

Khani, H., Feizi, M. A., Safaralizadeh, R., Mohseni, J., & Haghi, M. (2023). Altered Expression of the HLA-G and IL10RB Genes in Placental Tissue of Women with Recurrent Pregnancy Loss. Clinical Laboratory, 69(5).

Voloudakis, G., Vicari, J. M., Venkatesh, S., Hoffman, G. E., Dobrindt, K., Zhang, W., ... & Roussos, P. (2022). A translational genomics approach identifies IL10RB as the top candidate gene target for COVID-19 susceptibility. NPJ Genomic Medicine, 7(1), 52.

Maculewicz, E., Dzitkowska-Zabielska, M., Antkowiak, B., Antkowiak, O., Mastalerz, A., Garbacz, A., ... & Cięszczyk, P. (2022). Association of Interleukin Genes IL10 and IL10RB with Parameters of Overweight in Military Students. Genes, 13(2), 291.

Yazdani, R., Moazzami, B., Madani, S. P., Behniafard, N., Azizi, G., Aflatoonian, M., ... & Aghamohammadi, A. (2019). Candidiasis associated with very early onset inflammatory bowel disease: first IL10RB deficient case from the National Iranian Registry and review of the literature. Clinical immunology, 205, 35-42.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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