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Mouse Anti-IL10RB Recombinant Antibody (CBT2315) (V2LY-0625-LY1873)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT2315
Antibody Isotype
IgG1
Application
ICC, FC

Basic Information

Immunogen
Purified recombinant fragment of human IL10RB(AA: 20-220) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
ICC1:200-1:1,000
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
interleukin 10 receptor, beta
Entrez Gene ID
3588
UniProt ID
Q08334
Function
Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state.
Biological Process
Cytokine-mediated signaling pathway Source: GO_Central
Defense response to virus Source: UniProtKB-KW
Immune response Source: ProtInc
Inflammatory response Source: ProtInc
Positive regulation of cellular respiration Source: ARUK-UCL
Positive regulation of receptor signaling pathway via JAK-STAT Source: UniProtKB
Signal transduction Source: ProtInc
Cellular Location
Membrane
Involvement in disease
Inflammatory bowel disease 25, autosomal recessive (IBD25):
A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints.
Topology
Extracellular: 20-220
Helical: 221-242
Cytoplasmic: 243-325
More Infomation

Grk, M., Miskovic, R., Jeremic, I., Basaric, M., Dusanovic Pjevic, M., Jekic, B., ... & Banko, A. (2023). Association of IL10RA, IL10RB, and IL22RA Polymorphisms/Haplotypes with Susceptibility to and Clinical Manifestations of SLE. International Journal of Molecular Sciences, 24(14), 11292.

Mao, Z., Betti, M. J., Cedeno, M. A., Pedroza, L. A., Basaria, S., Liu, Q., ... & Markle, J. G. (2023). Clinical and cellular phenotypes resulting from a founder mutation in IL10RB. Clinical and Experimental Immunology, uxad085.

Khani, H., Feizi, M. A., Safaralizadeh, R., Mohseni, J., & Haghi, M. (2023). Altered Expression of the HLA-G and IL10RB Genes in Placental Tissue of Women with Recurrent Pregnancy Loss. Clinical Laboratory, 69(5).

Voloudakis, G., Vicari, J. M., Venkatesh, S., Hoffman, G. E., Dobrindt, K., Zhang, W., ... & Roussos, P. (2022). A translational genomics approach identifies IL10RB as the top candidate gene target for COVID-19 susceptibility. NPJ Genomic Medicine, 7(1), 52.

Maculewicz, E., Dzitkowska-Zabielska, M., Antkowiak, B., Antkowiak, O., Mastalerz, A., Garbacz, A., ... & Cięszczyk, P. (2022). Association of Interleukin Genes IL10 and IL10RB with Parameters of Overweight in Military Students. Genes, 13(2), 291.

Yazdani, R., Moazzami, B., Madani, S. P., Behniafard, N., Azizi, G., Aflatoonian, M., ... & Aghamohammadi, A. (2019). Candidiasis associated with very early onset inflammatory bowel disease: first IL10RB deficient case from the National Iranian Registry and review of the literature. Clinical immunology, 205, 35-42.

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For research use only. Not intended for any clinical use.

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