Mouse Anti-IL10RB Recombinant Antibody (CBT2315) (V2LY-0625-LY1873)

Name: Mouse Anti-IL10RB Recombinant Antibody (CBT2315)
SKU: V2LY-0625-LY1873
Rating: 5 (1 reviews)

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Tested Data

Mouse Anti-IL10RB Recombinant Antibody (CBT2315) (V2LY-0625-LY1873) in ELISA

Mouse Anti-IL10RB Recombinant Antibody (CBT2315) (V2LY-0625-LY1873) in WB

Mouse Anti-IL10RB Recombinant Antibody (CBT2315) (V2LY-0625-LY1873) in IF

Mouse Anti-IL10RB Recombinant Antibody (CBT2315) (V2LY-0625-LY1873) in FC

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBT2315

Application

ICC, FC

Immunogen

Purified recombinant fragment of human IL10RB(AA: 20-220) expressed in E. Coli.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:500-1:2,000
ICC	1:200-1:1,000
FC	1:200-1:400
ELISA	1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

Sodium azide

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

interleukin 10 receptor, beta

Entrez Gene ID

3588

UniProt ID

Q08334

Function

Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state.

Biological Process

Cytokine-mediated signaling pathway Source: GO_Central
Defense response to virus Source: UniProtKB-KW
Immune response Source: ProtInc
Inflammatory response Source: ProtInc
Positive regulation of cellular respiration Source: ARUK-UCL
Positive regulation of receptor signaling pathway via JAK-STAT Source: UniProtKB
Signal transduction Source: ProtInc

Cellular Location

Membrane

Involvement in disease

Inflammatory bowel disease 25, autosomal recessive (IBD25):
A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints.

Topology

Extracellular: 20-220
Helical: 221-242
Cytoplasmic: 243-325

Grk, M., Miskovic, R., Jeremic, I., Basaric, M., Dusanovic Pjevic, M., Jekic, B., ... & Banko, A. (2023). Association of IL10RA, IL10RB, and IL22RA Polymorphisms/Haplotypes with Susceptibility to and Clinical Manifestations of SLE. International Journal of Molecular Sciences, 24(14), 11292.

Mao, Z., Betti, M. J., Cedeno, M. A., Pedroza, L. A., Basaria, S., Liu, Q., ... & Markle, J. G. (2023). Clinical and cellular phenotypes resulting from a founder mutation in IL10RB. Clinical and Experimental Immunology, uxad085.

Khani, H., Feizi, M. A., Safaralizadeh, R., Mohseni, J., & Haghi, M. (2023). Altered Expression of the HLA-G and IL10RB Genes in Placental Tissue of Women with Recurrent Pregnancy Loss. Clinical Laboratory, 69(5).

Voloudakis, G., Vicari, J. M., Venkatesh, S., Hoffman, G. E., Dobrindt, K., Zhang, W., ... & Roussos, P. (2022). A translational genomics approach identifies IL10RB as the top candidate gene target for COVID-19 susceptibility. NPJ Genomic Medicine, 7(1), 52.

Maculewicz, E., Dzitkowska-Zabielska, M., Antkowiak, B., Antkowiak, O., Mastalerz, A., Garbacz, A., ... & Cięszczyk, P. (2022). Association of Interleukin Genes IL10 and IL10RB with Parameters of Overweight in Military Students. Genes, 13(2), 291.

Yazdani, R., Moazzami, B., Madani, S. P., Behniafard, N., Azizi, G., Aflatoonian, M., ... & Aghamohammadi, A. (2019). Candidiasis associated with very early onset inflammatory bowel disease: first IL10RB deficient case from the National Iranian Registry and review of the literature. Clinical immunology, 205, 35-42.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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