Human Recombinant IL10RB protein, His & hFc Tag-1 (V2LY-0526-LY4717)

Name: Human Recombinant IL10RB protein, His & hFc Tag-1
SKU: V2LY-0526-LY4717
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

His & hFc Tag

Protein Construction

This product is Human Recombinant IL10RB protein, His & hFc Tag consist of Amino Acid: 1-220 and predicts a molecular mass of 51.7 kDa.

Molecule Mass

51.7 kDa

Verified

HPLC

Sequence

Amino Acid: 1-220

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

≥92% as determined by SDS-PAGE. ≥90% as determined by SEC-HPLC.

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

interleukin 10 receptor, beta

Function

Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state.

Biological Process

Cytokine-mediated signaling pathway Source: GO_Central
Defense response to virus Source: UniProtKB-KW
Immune response Source: ProtInc
Inflammatory response Source: ProtInc
Positive regulation of cellular respiration Source: ARUK-UCL
Positive regulation of receptor signaling pathway via JAK-STAT Source: UniProtKB
Signal transduction Source: ProtInc

Cellular Location

Membrane

Involvement in disease

Inflammatory bowel disease 25, autosomal recessive (IBD25):
A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints.

Topology

Extracellular: 20-220
Helical: 221-242
Cytoplasmic: 243-325

Grk, M., Miskovic, R., Jeremic, I., Basaric, M., Dusanovic Pjevic, M., Jekic, B., ... & Banko, A. (2023). Association of IL10RA, IL10RB, and IL22RA Polymorphisms/Haplotypes with Susceptibility to and Clinical Manifestations of SLE. International Journal of Molecular Sciences, 24(14), 11292.

Mao, Z., Betti, M. J., Cedeno, M. A., Pedroza, L. A., Basaria, S., Liu, Q., ... & Markle, J. G. (2023). Clinical and cellular phenotypes resulting from a founder mutation in IL10RB. Clinical and Experimental Immunology, uxad085.

Khani, H., Feizi, M. A., Safaralizadeh, R., Mohseni, J., & Haghi, M. (2023). Altered Expression of the HLA-G and IL10RB Genes in Placental Tissue of Women with Recurrent Pregnancy Loss. Clinical Laboratory, 69(5).

Voloudakis, G., Vicari, J. M., Venkatesh, S., Hoffman, G. E., Dobrindt, K., Zhang, W., ... & Roussos, P. (2022). A translational genomics approach identifies IL10RB as the top candidate gene target for COVID-19 susceptibility. NPJ Genomic Medicine, 7(1), 52.

Maculewicz, E., Dzitkowska-Zabielska, M., Antkowiak, B., Antkowiak, O., Mastalerz, A., Garbacz, A., ... & Cięszczyk, P. (2022). Association of Interleukin Genes IL10 and IL10RB with Parameters of Overweight in Military Students. Genes, 13(2), 291.

Yazdani, R., Moazzami, B., Madani, S. P., Behniafard, N., Azizi, G., Aflatoonian, M., ... & Aghamohammadi, A. (2019). Candidiasis associated with very early onset inflammatory bowel disease: first IL10RB deficient case from the National Iranian Registry and review of the literature. Clinical immunology, 205, 35-42.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant IL10RB protein, His & hFc Tag (CAT#: V2LY-0526-LY4716)

Human Recombinant IL10RB protein, His Tag (CAT#: V2LY-0526-LY4718)

Human Recombinant IL10RB protein, His Tag-1 (CAT#: V2LY-0526-LY4719)

Mouse Recombinant IL10RB protein, hFc Tag (CAT#: V2LY-0526-LY8460)

Mouse Recombinant IL10RB protein, His Tag (CAT#: V2LY-0526-LY8461)

Rat Recombinant IL10RB protein, hFc Tag (CAT#: V2LY-0526-LY9435)

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Mouse Recombinant IL10RB protein, hFc Tag (CAT#: V2LY-0526-LY8460)

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Human Recombinant IL10RB protein, His & hFc Tag (CAT#: V2LY-0526-LY4716)

Mouse Anti-IL10RB Recombinant Antibody (CBT2315) (CAT#: V2LY-0625-LY1873)

Mouse Recombinant IL10RB protein, His Tag (CAT#: V2LY-0526-LY8461)

Human Recombinant IL10RB protein, His Tag (CAT#: V2LY-0526-LY4718)

Rat Recombinant IL10RB protein, hFc Tag (CAT#: V2LY-0526-LY9435)

Human Recombinant IL10RB protein, His Tag-1 (CAT#: V2LY-0526-LY4719)

Mouse Anti-IL10RB Recombinant Antibody (CBYY-I0804) (CAT#: CBMAB-I1789-YY)

Isotype control

For research use only. Not intended for any clinical use.

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