IL5RA

The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4. Several alternatively spliced transcript variants encoding four distinct isoforms have been reported. [provided by RefSeq, Jul 2011]

Interleukin 5 Receptor Subunit Alpha

This is the receptor for interleukin-5. The alpha chain binds to IL5.

Cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Inflammatory response to antigenic stimulusIEA:Ensembl
Positive regulation of leukocyte proliferationManual Assertion Based On ExperimentTAS:GO_Central
Regulation of interleukin-5 productionIEA:Ensembl
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc

Membrane

Extracellular: 21-342
Helical: 343-362
Cytoplasmic: 363-420