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Human Anti-IL5RA Recombinant Antibody (CBXC-0818) (CBMAB-C1932-CQ)

This product is a recombinant human antibody that recognizes IL5RA. The antibody CBXC-0818 can be used for immunoassay techniques such as: FC.
See all IL5RA antibodies

Summary

Host Animal
Human
Specificity
Mouse
Clone
CBXC-0818
Antibody Isotype
IgG1
Application
FC

Basic Information

Specificity
Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
Buffer containing stabilizer
Preservative
0.05% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Interleukin 5 Receptor Subunit Alpha
Introduction
The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4. Several alternatively spliced transcript variants encoding four distinct isoforms have been reported.
Entrez Gene ID
16192
UniProt ID
P21183
Alternative Names
Interleukin 5 Receptor Subunit Alpha
Function
This is the receptor for interleukin-5. The alpha chain binds to IL5.
Biological Process
Cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Inflammatory response to antigenic stimulusIEA:Ensembl
Positive regulation of leukocyte proliferationManual Assertion Based On ExperimentTAS:GO_Central
Regulation of interleukin-5 productionIEA:Ensembl
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Membrane
Topology
Extracellular: 21-342
Helical: 343-362
Cytoplasmic: 363-420

Xu, C., Gao, M., Zhang, J., & Fu, Y. (2023). IL5RA as an immunogenic cell death-related predictor in progression and therapeutic response of multiple myeloma. Scientific Reports, 13(1), 8528.

Zhu, Q., Chen, H., Li, X., Wang, X., & Yan, H. (2022). JMJD2C mediates the MDM2/p53/IL5RA axis to promote CDDP resistance in uveal melanoma. Cell Death Discovery, 8(1), 227.

Sivaraj, N., Rachel, K. V., Suvvari, T. K., Prasad, S., Boppana, S., Naidu, V., ... & Kutikuppala, L. S. (2022). Association of SNP rs163550 in IL5RA Gene with Risk of Preeclampsia. Journal of the Scientific Society, 49(3), 272-276.

Laffey, K. G., Du, J., Schrum, A. G., & Ackerman, S. J. (2021). Transcriptional Regulation of the Human IL5RA Gene through Alternative Promoter Usage during Eosinophil Development. International Journal of Molecular Sciences, 22(19), 10245.

Lin, X., & Lin, Q. (2020). MiRNA-495-3p attenuates TNF-α induced apoptosis and inflammation in human nucleus pulposus cells by targeting IL5RA. Inflammation, 43, 1797-1805.

Klös, M., Thürmann, L., Bauer, M., Heinrich, J., Standl, M., von Berg, A., ... & Lehmann, I. (2019). Longitudinal trends of serum IgE and IL5RA expression throughout childhood are associated with asthma but not with persistent wheeze. Allergy, 74(10), 2002-2006.

Bagnasco, D., Caminati, M., Ferrando, M., Aloè, T., Testino, E., Canonica, G. W., & Passalacqua, G. (2018). Anti-IL-5 and IL-5Ra: efficacy and safety of new therapeutic strategies in severe uncontrolled asthma. BioMed Research International, 2018.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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