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Mouse Anti-IL5RA Recombinant Antibody (CBT2346) (V2LY-0625-LY1131)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT2346
Antibody Isotype
IgG1
Application
FC

Basic Information

Immunogen
Purified recombinant fragment of human CD125 (AA: extra 21-196) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Interleukin 5 Receptor Subunit Alpha
Entrez Gene ID
3568
UniProt ID
Q01344
Function
This is the receptor for interleukin-5. The alpha chain binds to IL5.
Biological Process
Cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Inflammatory response to antigenic stimulusIEA:Ensembl
Positive regulation of leukocyte proliferationManual Assertion Based On ExperimentTAS:GO_Central
Regulation of interleukin-5 productionIEA:Ensembl
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Membrane
Topology
Extracellular: 21-342
Helical: 343-362
Cytoplasmic: 363-420
More Infomation

Xu, C., Gao, M., Zhang, J., & Fu, Y. (2023). IL5RA as an immunogenic cell death-related predictor in progression and therapeutic response of multiple myeloma. Scientific Reports, 13(1), 8528.

Zhu, Q., Chen, H., Li, X., Wang, X., & Yan, H. (2022). JMJD2C mediates the MDM2/p53/IL5RA axis to promote CDDP resistance in uveal melanoma. Cell Death Discovery, 8(1), 227.

Sivaraj, N., Rachel, K. V., Suvvari, T. K., Prasad, S., Boppana, S., Naidu, V., ... & Kutikuppala, L. S. (2022). Association of SNP rs163550 in IL5RA Gene with Risk of Preeclampsia. Journal of the Scientific Society, 49(3), 272-276.

Laffey, K. G., Du, J., Schrum, A. G., & Ackerman, S. J. (2021). Transcriptional Regulation of the Human IL5RA Gene through Alternative Promoter Usage during Eosinophil Development. International Journal of Molecular Sciences, 22(19), 10245.

Lin, X., & Lin, Q. (2020). MiRNA-495-3p attenuates TNF-α induced apoptosis and inflammation in human nucleus pulposus cells by targeting IL5RA. Inflammation, 43, 1797-1805.

Klös, M., Thürmann, L., Bauer, M., Heinrich, J., Standl, M., von Berg, A., ... & Lehmann, I. (2019). Longitudinal trends of serum IgE and IL5RA expression throughout childhood are associated with asthma but not with persistent wheeze. Allergy, 74(10), 2002-2006.

Bagnasco, D., Caminati, M., Ferrando, M., Aloè, T., Testino, E., Canonica, G. W., & Passalacqua, G. (2018). Anti-IL-5 and IL-5Ra: efficacy and safety of new therapeutic strategies in severe uncontrolled asthma. BioMed Research International, 2018.

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For research use only. Not intended for any clinical use.

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