INAVA

INAVA (Innate Immunity Activator) is a Protein Coding gene. An important paralog of this gene is FRMD4A.

Full Name

Innate Immunity Activator

Function

Expressed in peripheral macrophages and intestinal myeloid-derived cells, is required for optimal PRR (pattern recognition receptor)-induced signaling, cytokine secretion, and bacterial clearance. Upon stimulation of a broad range of PRRs (pattern recognition receptor) such as NOD2 or TLR2, TLR3, TLR4, TLR5, TLR7 and TLR9, associates with YWHAQ/14-3-3T, which in turn leads to the recruitment and activation of MAP kinases and NF-kappa-B signaling complexes that amplifies PRR-induced downstream signals and cytokine secretion (PubMed:28436939).
In the intestine, regulates adherens junction stability by regulating the degradation of CYTH1 and CYTH2, probably acting as substrate cofactor for SCF E3 ubiquitin-protein ligase complexes. Stabilizes adherens junctions by limiting CYTH1-dependent ARF6 activation (PubMed:29420262).

Biological Process

Adherens junction maintenanceManual Assertion Based On ExperimentIMP:UniProtKB
Innate immune responseManual Assertion Based On ExperimentIMP:UniProtKB
Intestinal epithelial structure maintenanceISS:UniProtKB
Nucleotide-binding oligomerization domain containing 2 signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Pattern recognition receptor signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of cytokine production involved in immune responseManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of I-kappaB kinase/NF-kappaB signalingManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of interleukin-1 beta productionManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of interleukin-10 productionManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of interleukin-6 productionManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of MAPK cascadeManual Assertion Based On ExperimentIMP:GO_Central
Positive regulation of protein ubiquitinationManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of stress-activated MAPK cascadeManual Assertion Based On ExperimentIMP:UniProtKB
Reactive oxygen species biosynthetic processManual Assertion Based On ExperimentIMP:UniProtKB
Response to muramyl dipeptideManual Assertion Based On ExperimentIMP:UniProtKB
Response to peptidoglycanManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Nucleus; Cytoplasm. Translocates to the nucleus upon NOD2 stimulation.

Involvement in disease

Inflammatory bowel disease 29 (IBD29):
A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints.