Mouse Anti-INAVA Recombinant Antibody (CBWJC-3844) (CBMAB-C5121WJ)

This product is a Mouse antibody that recognizes INAVA. This antibody CBWJC-3844 can be used for immunoassay techniques such as: WB, IHC.
See all INAVA antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBWJC-3844

Antibody Isotype

IgG1

Application

WB, IHC

Basic Information

Immunogen

Human recombinant protein fragment corresponding to aa1-270 of human C1ORF106(NP_060735) produced in E.coli

Specificity

Human

Antibody Isotype

IgG1

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS (PH 7.3), 1% BSA, 50% glycerol

Preservative

0.02% sodium azide

Concentration

1 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

Innate Immunity Activator

Introduction

INAVA (Innate Immunity Activator) is a Protein Coding gene. An important paralog of this gene is FRMD4A.

Entrez Gene ID

55765

UniProt ID

Q3KP66

Alternative Names

Innate Immunity Activator

Function

Expressed in peripheral macrophages and intestinal myeloid-derived cells, is required for optimal PRR (pattern recognition receptor)-induced signaling, cytokine secretion, and bacterial clearance. Upon stimulation of a broad range of PRRs (pattern recognition receptor) such as NOD2 or TLR2, TLR3, TLR4, TLR5, TLR7 and TLR9, associates with YWHAQ/14-3-3T, which in turn leads to the recruitment and activation of MAP kinases and NF-kappa-B signaling complexes that amplifies PRR-induced downstream signals and cytokine secretion (PubMed:28436939).
In the intestine, regulates adherens junction stability by regulating the degradation of CYTH1 and CYTH2, probably acting as substrate cofactor for SCF E3 ubiquitin-protein ligase complexes. Stabilizes adherens junctions by limiting CYTH1-dependent ARF6 activation (PubMed:29420262).

Biological Process

Adherens junction maintenanceManual Assertion Based On ExperimentIMP:UniProtKB
Innate immune responseManual Assertion Based On ExperimentIMP:UniProtKB
Intestinal epithelial structure maintenanceISS:UniProtKB
Nucleotide-binding oligomerization domain containing 2 signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Pattern recognition receptor signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of cytokine production involved in immune responseManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of I-kappaB kinase/NF-kappaB signalingManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of interleukin-1 beta productionManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of interleukin-10 productionManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of interleukin-6 productionManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of MAPK cascadeManual Assertion Based On ExperimentIMP:GO_Central
Positive regulation of protein ubiquitinationManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of stress-activated MAPK cascadeManual Assertion Based On ExperimentIMP:UniProtKB
Reactive oxygen species biosynthetic processManual Assertion Based On ExperimentIMP:UniProtKB
Response to muramyl dipeptideManual Assertion Based On ExperimentIMP:UniProtKB
Response to peptidoglycanManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Nucleus; Cytoplasm. Translocates to the nucleus upon NOD2 stimulation.

Involvement in disease

Inflammatory bowel disease 29 (IBD29):
A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints.

References

Mamoor, S. (2023). INAVA is differentially expressed in central nervous system metastasis in human breast cancer.

Saulle, I., Marventano, I., Saresella, M., Vanetti, C., Garziano, M., Fenizia, C., ... & Biasin, M. (2021). ERAPs reduce in vitro HIV infection by activating innate immune response. The Journal of Immunology, 206(7), 1609-1617.

Luong, P., Lencer, W., Chang, D., & Li, Q. (2020). P145 MECHANISMS OF ACTION FOR THE IBD-RISK GENE C1ORF106/INAVA. Gastroenterology, 158(3), S48.

Ma, J., Liu, C., Yang, D., Song, J., Zhang, J., Wang, T., ... & Zhang, H. (2019). C1orf106, an innate immunity activator, is amplified in breast cancer and is required for basal-like/luminal progenitor fate decision. Science China Life Sciences, 62, 1229-1242.

Guan, H., Guo, Y., Liu, L., Ye, R., Liang, W., Li, H., ... & Li, Y. (2018). INAVA promotes aggressiveness of papillary thyroid cancer by upregulating MMP9 expression. Cell & Bioscience, 8(1), 1-14.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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