KLK6

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. The encoded enzyme is regulated by steroid hormones. In tissue culture, the enzyme has been found to generate amyloidogenic fragments from the amyloid precursor protein, suggesting a potential for involvement in Alzheimer's disease. Multiple alternatively spliced transcript variants that encode different isoforms have been identified for this gene. [provided by RefSeq]

kallikrein-related peptidase 6

Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. May be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis.

Amyloid precursor protein metabolic process1 PublicationNAS:UniProtKB
Central nervous system development1 PublicationNAS:UniProtKB
Collagen catabolic process1 PublicationNAS:UniProtKB
Hormone metabolic process1 PublicationNAS:UniProtKB
Myelination1 PublicationNAS:UniProtKB
Positive regulation of G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Protein autoprocessing1 PublicationNAS:UniProtKB
Regulation of cell differentiation1 PublicationNAS:UniProtKB
Regulation of neuron projection developmentIEA:Ensembl
Response to wounding1 PublicationNAS:UniProtKB
Tissue regeneration1 PublicationNAS:UniProtKB

Secreted
Nucleus, nucleolus
Cytoplasm
Mitochondrion
Microsome
In brain, detected in the nucleus of glial cells and in the nucleus and cytoplasm of neurons. Detected in the mitochondrial and microsomal fractions of HEK-293 cells and released into the cytoplasm following cell stress.

Inactivated by autolytic cleavage after Arg-80.