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Mouse Anti-KLK6 Recombinant Antibody (E2) (CBMAB-K1305-LY)

This product is antibody recognizes KLK6. The antibody E2 immunoassay techniques such as: ELISA, WB.
See all KLK6 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
E2
Antibody Isotype
IgG
Application
ELISA, WB

Basic Information

Immunogen
Recombinant protein corresponding to aa 17-244 of human kallikrein-6 (His-tagged)
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
10% glycerol
Preservative
0.05% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
kallikrein-related peptidase 6
Introduction
This gene encodes a member of the kallikrein subfamily of the peptidase S1 family of serine proteases. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. The encoded preproprotein is proteolytically processed to generate the mature protease. Expression of this protease is regulated by steroid hormones and may be elevated in multiple human cancers and in serum from psoriasis patients. The encoded protease may participate in the cleavage of amyloid precursor protein and alpha-synuclein, thus implicating this protease in Alzheimer's and Parkinson's disease, respectively. This gene is located in a gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]
Entrez Gene ID
5653
UniProt ID
Q92876
Alternative Names
Kallikrein Related Peptidase 6; Serine Protease 18; Serine Protease 9; Protease M; Neurosin; PRSS18; PRSS9; ZYME; SP59; Kallikrein 6 (Neurosin; Zyme);
Function
Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. May be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis.
Biological Process
Amyloid precursor protein metabolic process1 PublicationNAS:UniProtKB
Central nervous system development1 PublicationNAS:UniProtKB
Collagen catabolic process1 PublicationNAS:UniProtKB
Hormone metabolic process1 PublicationNAS:UniProtKB
Myelination1 PublicationNAS:UniProtKB
Positive regulation of G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Protein autoprocessing1 PublicationNAS:UniProtKB
Regulation of cell differentiation1 PublicationNAS:UniProtKB
Regulation of neuron projection developmentIEA:Ensembl
Response to wounding1 PublicationNAS:UniProtKB
Tissue regeneration1 PublicationNAS:UniProtKB
Cellular Location
Secreted
Nucleus, nucleolus
Cytoplasm
Mitochondrion
Microsome
In brain, detected in the nucleus of glial cells and in the nucleus and cytoplasm of neurons. Detected in the mitochondrial and microsomal fractions of HEK-293 cells and released into the cytoplasm following cell stress.
PTM
Inactivated by autolytic cleavage after Arg-80.

Bouzid, H., Soualmia, F., Oikonomopoulou, K., Soosaipillai, A., Walker, F., Louati, K., ... & Darmoul, D. (2022). Kallikrein-related peptidase 6 (KLK6) as a contributor toward an aggressive cancer cell phenotype: A potential role in colon cancer peritoneal metastasis. Biomolecules, 12(7), 1003.

Yoon, H., Triplet, E. M., Simon, W. L., Choi, C. I., Kleppe, L. S., De Vita, E., ... & Scarisbrick, I. A. (2022). Blocking Kallikrein 6 promotes developmental myelination. Glia, 70(3), 430-450.

Zhou, D., He, Y., Li, H., & Huang, W. (2021). Silencing of kallikrein‑related peptidase 6 attenuates the proliferation, migration, and invasion of gastric cancer cells through inhibition of epithelial‑mesenchymal transition. Experimental and Therapeutic Medicine, 22(1), 1-10.

Yuan, L., Zou, D., Yang, X., Chen, X., Lu, Y., Zhang, A., ... & Wei, F. (2021). Proteomics and functional study reveal kallikrein-6 enhances communicating hydrocephalus. Clinical Proteomics, 18(1), 1-12.

Chen, H., Sells, E., Pandey, R., Abril, E. R., Hsu, C. H., Krouse, R. S., ... & Ignatenko, N. A. (2019). Kallikrein 6 protease advances colon tumorigenesis via induction of the high mobility group A2 protein. Oncotarget, 10(58), 6062.

Haritos, C., Michaelidou, K., Mavridis, K., Missitzis, I., Ardavanis, A., Griniatsos, J., & Scorilas, A. (2018). Kallikrein-related peptidase 6 (KLK6) expression differentiates tumor subtypes and predicts clinical outcome in breast cancer patients. Clinical and Experimental Medicine, 18, 203-213.

Sananes, A., Cohen, I., Shahar, A., Hockla, A., De Vita, E., Miller, A. K., ... & Papo, N. (2018). A potent, proteolysis-resistant inhibitor of kallikrein-related peptidase 6 (KLK6) for cancer therapy, developed by combinatorial engineering. Journal of Biological Chemistry, 293(33), 12663-12680.

Patra, K., Soosaipillai, A., Sando, S. B., Lauridsen, C., Berge, G., Møller, I., ... & Nielsen, H. M. (2018). Assessment of kallikrein 6 as a cross-sectional and longitudinal biomarker for Alzheimer’s disease. Alzheimer's Research & Therapy, 10, 1-11.

Bando, Y., Hagiwara, Y., Suzuki, Y., Yoshida, K., Aburakawa, Y., Kimura, T., ... & Yoshida, S. (2018). Kallikrein 6 secreted by oligodendrocytes regulates the progression of experimental autoimmune encephalomyelitis. Glia, 66(2), 359-378.

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For research use only. Not intended for any clinical use.

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