LIMS1

LIMS1 is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in integrin-mediated cell adhesion or spreading.

LIM zinc finger domain containing 1

Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. Involved in the regulation of cell survival, cell proliferation and cell differentiation.

Cell agingManual Assertion Based On ExperimentTAS:ProtInc
Cell-cell adhesionManual Assertion Based On ExperimentIBA:GO_Central
Cell-cell junction organizationManual Assertion Based On ExperimentIBA:GO_Central
Cellular response to transforming growth factor beta stimulusManual Assertion Based On ExperimentIEP:UniProtKB
Establishment of protein localizationManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of cell-substrate adhesionManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of focal adhesion assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of gene expressionManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of GTPase activityManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of integrin-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of NIK/NF-kappaB signalingManual Assertion Based On ExperimentIMP:CAFA
Positive regulation of substrate adhesion-dependent cell spreadingManual Assertion Based On ExperimentIMP:UniProtKB
Tumor necrosis factor-mediated signaling pathwayManual Assertion Based On ExperimentIMP:CAFA

Cell junction, focal adhesion
Cell membrane