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Mouse Anti-LIMS1 Recombinant Antibody (49/PINCH) (CBMAB-P0468-YC)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat, Chicken, Dog
Clone
49/PINCH
Antibody Isotype
IgG2a
Application
WB

Basic Information

Immunogen
Human PINCH, AA 120-220
Specificity
Human, Mouse, Rat, Chicken, Dog
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
LIM zinc finger domain containing 1
Introduction
LIMS1 is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in integrin-mediated cell adhesion or spreading.
Entrez Gene ID
Human3987
Mouse110829
Rat499443
Chicken414880
Dog474540
UniProt ID
HumanP48059
MouseQ99JW4
RatC0KUC5
ChickenQ5ZL81
DogE2RKQ1
Alternative Names
PINCH; PINCH1; PINCH-1
Function
Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. Involved in the regulation of cell survival, cell proliferation and cell differentiation.
Biological Process
Cell agingManual Assertion Based On ExperimentTAS:ProtInc
Cell-cell adhesionManual Assertion Based On ExperimentIBA:GO_Central
Cell-cell junction organizationManual Assertion Based On ExperimentIBA:GO_Central
Cellular response to transforming growth factor beta stimulusManual Assertion Based On ExperimentIEP:UniProtKB
Establishment of protein localizationManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of cell-substrate adhesionManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of focal adhesion assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of gene expressionManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of GTPase activityManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of integrin-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of NIK/NF-kappaB signalingManual Assertion Based On ExperimentIMP:CAFA
Positive regulation of substrate adhesion-dependent cell spreadingManual Assertion Based On ExperimentIMP:UniProtKB
Tumor necrosis factor-mediated signaling pathwayManual Assertion Based On ExperimentIMP:CAFA
Cellular Location
Cell junction, focal adhesion
Cell membrane
More Infomation

Sun, Z., Zhang, Z., Banu, K., Gibson, I. W., Colvin, R. B., Yi, Z., ... & Menon, M. C. (2023). Multiscale genetic architecture of donor-recipient differences reveals intronic LIMS1 mismatches associated with kidney transplant survival. The Journal of clinical investigation, 133(21).

Shi, J., Jia, Z., Zhou, Z., Zhao, L., Meng, Q., & Liu, Y. (2023). Ineffectiveness of Crizotinib in a Non-Small-Cell Lung Cancer with Novel ALK-LIMS1 Fusion: A Case Report. OncoTargets and Therapy, 109-114.

Sun, Z., Zhang, Z., Banu, K., Gibson, I., Colvin, R., Yi, Z., ... & Menon, M. C. (2022). Multiscale genetic architecture of donor-recipient differences reveals intronic LIMS1 locus mismatches associated with long-term renal transplant survival. bioRxiv, 2022-12.

Caliskan, Y., Karahan, G., Akgul, S. U., Mirioglu, S., Ozluk, Y., Yazici, H., ... & Lentine, K. L. (2021). LIMS1 risk genotype and T cell–mediated rejection in kidney transplant recipients. Nephrology Dialysis Transplantation, 36(11), 2120-2129.

Huang, C., Li, Y., Li, Z., Xu, Y., Li, N., Ge, Y., ... & Ren, H. (2019). LIMS1 promotes pancreatic cancer cell survival under oxygen–glucose deprivation conditions by enhancing HIF1A protein translation. Clinical Cancer Research, 25(13), 4091-4103.

Steers, N. J., Li, Y., Drace, Z., D’Addario, J. A., Fischman, C., Liu, L., ... & Kiryluk, K. (2019). Genomic mismatch at LIMS1 locus and kidney allograft rejection. New England Journal of Medicine, 380(20), 1918-1928.

Saeki, N., Saito, A., Sugaya, Y., Amemiya, M., Ono, H., Komatsuzaki, R., ... & Sasaki, H. (2018). Chromatin immunoprecipitation and DNA sequencing identified a LIMS1/ILK pathway regulated by LMO1 in neuroblastoma. Cancer Genomics & Proteomics, 15(3), 165-174.

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For research use only. Not intended for any clinical use.

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