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Mouse Anti-LIMS1 Recombinant Antibody (CBT2461) (V2LY-0625-LY2588)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT2461
Antibody Isotype
IgG1
Application
ICC, FC

Basic Information

Immunogen
Purified recombinant fragment of human PINCH expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
ICC1:200-1:1,000
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Preservative
Sodium azide
Concentration
Batch dependent
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
LIM zinc finger domain containing 1
Entrez Gene ID
3987
UniProt ID
P48059
Function
Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. Involved in the regulation of cell survival, cell proliferation and cell differentiation.
Biological Process
Cell agingManual Assertion Based On ExperimentTAS:ProtInc
Cell-cell adhesionManual Assertion Based On ExperimentIBA:GO_Central
Cell-cell junction organizationManual Assertion Based On ExperimentIBA:GO_Central
Cellular response to transforming growth factor beta stimulusManual Assertion Based On ExperimentIEP:UniProtKB
Establishment of protein localizationManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of cell-substrate adhesionManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of focal adhesion assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of gene expressionManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of GTPase activityManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of integrin-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of NIK/NF-kappaB signalingManual Assertion Based On ExperimentIMP:CAFA
Positive regulation of substrate adhesion-dependent cell spreadingManual Assertion Based On ExperimentIMP:UniProtKB
Tumor necrosis factor-mediated signaling pathwayManual Assertion Based On ExperimentIMP:CAFA
Cellular Location
Cell junction, focal adhesion
Cell membrane
More Infomation

Sun, Z., Zhang, Z., Banu, K., Gibson, I. W., Colvin, R. B., Yi, Z., ... & Menon, M. C. (2023). Multiscale genetic architecture of donor-recipient differences reveals intronic LIMS1 mismatches associated with kidney transplant survival. The Journal of clinical investigation, 133(21).

Shi, J., Jia, Z., Zhou, Z., Zhao, L., Meng, Q., & Liu, Y. (2023). Ineffectiveness of Crizotinib in a Non-Small-Cell Lung Cancer with Novel ALK-LIMS1 Fusion: A Case Report. OncoTargets and Therapy, 109-114.

Sun, Z., Zhang, Z., Banu, K., Gibson, I., Colvin, R., Yi, Z., ... & Menon, M. C. (2022). Multiscale genetic architecture of donor-recipient differences reveals intronic LIMS1 locus mismatches associated with long-term renal transplant survival. bioRxiv, 2022-12.

Caliskan, Y., Karahan, G., Akgul, S. U., Mirioglu, S., Ozluk, Y., Yazici, H., ... & Lentine, K. L. (2021). LIMS1 risk genotype and T cell–mediated rejection in kidney transplant recipients. Nephrology Dialysis Transplantation, 36(11), 2120-2129.

Huang, C., Li, Y., Li, Z., Xu, Y., Li, N., Ge, Y., ... & Ren, H. (2019). LIMS1 promotes pancreatic cancer cell survival under oxygen–glucose deprivation conditions by enhancing HIF1A protein translation. Clinical Cancer Research, 25(13), 4091-4103.

Steers, N. J., Li, Y., Drace, Z., D’Addario, J. A., Fischman, C., Liu, L., ... & Kiryluk, K. (2019). Genomic mismatch at LIMS1 locus and kidney allograft rejection. New England Journal of Medicine, 380(20), 1918-1928.

Saeki, N., Saito, A., Sugaya, Y., Amemiya, M., Ono, H., Komatsuzaki, R., ... & Sasaki, H. (2018). Chromatin immunoprecipitation and DNA sequencing identified a LIMS1/ILK pathway regulated by LMO1 in neuroblastoma. Cancer Genomics & Proteomics, 15(3), 165-174.

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For research use only. Not intended for any clinical use.

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