LINGO1

LINGO1 (Leucine Rich Repeat And Ig Domain Containing 1) is a protein coding gene. Diseases associated with LINGO1 include Essential Tremor. Among its related pathways areCytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases and RET signaling. And an important paralog is LINGO2.

Leucine Rich Repeat and Ig Domain Containing 1

Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors (PubMed:14966521, PubMed:15694321).
Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination (PubMed:15895088).
Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development (By similarity).

Cell membrane

Mental retardation, autosomal recessive 64 (MRT64):
A form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRT64 patients have moderate to severe intellectual disability, delayed motor development, aggressive behavior, and slurred or absent speech.

Extracellular: 42-561
Helical: 562-582
Cytoplasmic: 583-620

N-glycosylated. Contains predominantly high-mannose glycans.