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Mouse Anti-LINGO1 Recombinant Antibody (CBYJL-1762) (CBMAB-L1672-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to Leucine Rich Repeat And Ig Domain Containing 1 (LINGO1). The antibody can be used for immunoassay techniques, such as FC.
See all LINGO1 antibodies
Published Data
Fig.1 Loss of NgR1 leads to increased phosphorylation of ERK.
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Fig.2 Overexpression of LINGO-1 prevents OPC maturation.
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Fig.3 LINGO-1 expression decreases during OPC maturation in vitro.
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Fig.4 confocal fluorescence microscopic image of the soma of a single cultured mouse cerebellar granule neuron following covalent labeling of plasma membrane proteins with biotin.
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Fig.5 immunoblot (IB) results of streptavidin bead pulldown assay with non-permeabilized (Non-perm.)
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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJL-1762
Antibody Isotype
IgG1
Application
FC

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Leucine Rich Repeat and Ig Domain Containing 1
Introduction
Diseases associated with LINGO1 include Essential Tremor. Among its related pathways are p75 NTR receptor-mediated signalling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include epidermal growth factor receptor binding. An important paralog of this gene is LINGO2. LINGO1 is a functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. LINGO1 is also an important negative regulator of oligodentrocyte differentiation and axonal myelination. LINGO1 acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development (By similarity).
Entrez Gene ID
84894
UniProt ID
Q96FE5
Alternative Names
LERN1; LRRN6A; UNQ201
Function
Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors (PubMed:14966521, PubMed:15694321).
Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination (PubMed:15895088).
Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development (By similarity).
Cellular Location
Cell membrane
Involvement in disease
Mental retardation, autosomal recessive 64 (MRT64):
A form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRT64 patients have moderate to severe intellectual disability, delayed motor development, aggressive behavior, and slurred or absent speech.
Topology
Extracellular: 42-561
Helical: 562-582
Cytoplasmic: 583-620
PTM
N-glycosylated. Contains predominantly high-mannose glycans.

Zhou, Y. N., Jiang, L., Zhang, Y., Zhou, C. N., Yang, H., He, Q., ... & Chao, F. L. (2023). Anti-LINGO-1 antibody protects neurons and synapses in the medial prefrontal cortex of APP/PS1 transgenic mice. Neuroscience Research.

Yang, H., Jiang, L., Zhang, Y., Liang, X., Tang, J., He, Q., ... & Tang, Y. (2022). Anti‐LINGO‐1 antibody treatment alleviates cognitive deficits and promotes maturation of oligodendrocytes in the hippocampus of APP/PS1 mice. Journal of Comparative Neurology, 530(10), 1606-1621.

Xie, Y. H., Zhou, C. N., Liang, X., Tang, J., Yang, C. M., Luo, Y. M., ... & Tang, Y. (2021). Anti‐Lingo‐1 antibody ameliorates spatial memory and synapse loss induced by chronic stress. Journal of Comparative Neurology, 529(7), 1571-1583.

Yang, C., Tang, J., Liang, X., Qi, Y., Luo, Y., Xie, Y., ... & Tang, Y. (2020). Anti-LINGO-1 antibody treatment improves chronic stress-induced spatial memory impairments and oligodendrocyte loss in the hippocampus. Behavioural Brain Research, 393, 112765.

Dudem, S., Large, R. J., Kulkarni, S., McClafferty, H., Tikhonova, I. G., Sergeant, G. P., ... & Hollywood, M. A. (2020). LINGO1 is a regulatory subunit of large conductance, Ca2+-activated potassium channels. Proceedings of the National Academy of Sciences, 117(4), 2194-2200.

Wu, Y., Zhan, Z., Quan, Y., Yang, Y., Chen, X., Liu, L., ... & Yu, M. (2020). SP1‐mediated upregulation of LINGO‐1 promotes degeneration of retinal ganglion cells in optic nerve injury. CNS Neuroscience & Therapeutics, 26(10), 1010-1020.

Hanf, K. J., Arndt, J. W., Liu, Y., Gong, B. J., Rushe, M., Sopko, R., ... & Pepinsky, R. B. (2020, January). Functional activity of anti-LINGO-1 antibody opicinumab requires target engagement at a secondary binding site. In MAbs (Vol. 12, No. 1, p. 1713648). Taylor & Francis.

Huang, L. J., Li, G., Ding, Y., Sun, J. H., Wu, T. T., Zhao, W., & Zeng, Y. S. (2019). LINGO-1 deficiency promotes nerve regeneration through reduction of cell apoptosis, inflammation, and glial scar after spinal cord injury in mice. Experimental Neurology, 320, 112965.

Ansar, M., Riazuddin, S., Sarwar, M. T., Makrythanasis, P., Paracha, S. A., Iqbal, Z., ... & Antonarakis, S. E. (2018). Biallelic variants in LINGO1 are associated with autosomal recessive intellectual disability, microcephaly, speech and motor delay. Genetics in Medicine, 20(7), 778-784.

Wu, D., Tang, X., Gu, L. H., Li, X. L., Qi, X. Y., Bai, F., ... & Zhang, Z. J. (2018). LINGO‐1 antibody ameliorates myelin impairment and spatial memory deficits in the early stage of 5 XFAD mice. CNS neuroscience & therapeutics, 24(5), 381-393.

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For research use only. Not intended for any clinical use.

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