LRP12

This gene encodes a member of the low-density lipoprotein receptor related protein family. The product of this gene is a transmembrane protein that is differentially expressed in many cancer cells. Alternate splicing results in multiple transcript variants.

low density lipoprotein-related protein 12

Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. May act as a tumor suppressor.

Endocytosis1 PublicationNAS:UniProtKB
Neuron migrationManual Assertion Based On ExperimentIDA:MGI
Neuron projection developmentManual Assertion Based On ExperimentIDA:MGI
Regulation of growth1 PublicationNAS:UniProtKB
Signal transduction1 PublicationNAS:UniProtKB

Membrane
Membrane, coated pit

Oculopharyngodistal myopathy 1 (OPDM1):
A form of oculopharyngodistal myopathy, a muscle disorder characterized by progressive ptosis, external ophthalmoplegia, and weakness of the masseter, facial, pharyngeal, and distal limb muscles. The myopathological features are presence of rimmed vacuoles in the muscle fibers and myopathic changes of differing severity. OPDM1 inheritance pattern is autosomal dominant.

Extracellular: 33-492
Helical: 493-513
Cytoplasmic: 514-859