Mouse Anti-LRP12 Recombinant Antibody (CBT3583) (V2LY-0625-LY1126)

Name: Mouse Anti-LRP12 Recombinant Antibody (CBT3583)
SKU: V2LY-0625-LY1126
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBT3583

Antibody Isotype

IgG2b

Application

Basic Information

Immunogen

Purified recombinant fragment of human LRP12 (AA: extra 355-492) expressed in E. Coli.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2b

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:500-1:2,000
FC	1:200-1:400
ELISA	1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

Sodium azide

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

low density lipoprotein-related protein 12

Entrez Gene ID

29967

UniProt ID

Q9Y561

Function

Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. May act as a tumor suppressor.

Biological Process

Endocytosis1 PublicationNAS:UniProtKB
Neuron migrationManual Assertion Based On ExperimentIDA:MGI
Neuron projection developmentManual Assertion Based On ExperimentIDA:MGI
Regulation of growth1 PublicationNAS:UniProtKB
Signal transduction1 PublicationNAS:UniProtKB

Cellular Location

Membrane
Membrane, coated pit

Involvement in disease

Oculopharyngodistal myopathy 1 (OPDM1):
A form of oculopharyngodistal myopathy, a muscle disorder characterized by progressive ptosis, external ophthalmoplegia, and weakness of the masseter, facial, pharyngeal, and distal limb muscles. The myopathological features are presence of rimmed vacuoles in the muscle fibers and myopathic changes of differing severity. OPDM1 inheritance pattern is autosomal dominant.

Topology

Extracellular: 33-492
Helical: 493-513
Cytoplasmic: 514-859

More Infomation

References

Zeng, Z., Dai, Y., Deng, S., Zou, S., Dou, T., & Wei, F. (2022). Synovial mesenchymal stem cell-derived extracellular vesicles alleviate chondrocyte damage during osteoarthritis through microRNA-130b-3p-mediated inhibition of the LRP12/AKT/β-catenin axis. Immunopharmacology and Immunotoxicology, 44(2), 247-260.

Shyl, E. S. D., Malgija, B., Iniyan, A. M., Mahendran, R., & Vincent, S. G. P. (2022). Mining of transcriptome identifies CD109 and LRP12 as possible biomarkers and deregulation mechanism of T cell receptor pathway in Acute Myeloid Leukemia. Heliyon, 8(10), e11123.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Related Products

Mouse Anti-LRP12 Recombinant Antibody (CBT2954)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Datasheet
SDS
Request for COA

Request bulk or custom quote
Second antibody and isotype control

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