LY96

This gene encodes a protein which associates with toll-like receptor 4 on the cell surface and confers responsiveness to lipopolysaccyaride (LPS), thus providing a link between the receptor and LPS signaling.
Full Name
LY96
Function
Binds bacterial lipopolysaccharide (LPS) (PubMed:17803912, PubMed:17569869).
Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria (PubMed:11160242, PubMed:11593030).
Enhances TLR4-dependent activation of NF-kappa-B (PubMed:10359581).
Cells expressing both LY96 and TLR4, but not TLR4 alone, respond to LPS (PubMed:10359581).
Biological Process
Cell surface receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Cellular defense responseManual Assertion Based On ExperimentTAS:ProtInc
Cellular response to lipopolysaccharideManual Assertion Based On ExperimentIBA:GO_Central
Detection of lipopolysaccharideManual Assertion Based On ExperimentIDA:UniProtKB
Inflammatory responseIEA:UniProtKB-KW
Innate immune response1 PublicationIC:ComplexPortal
Positive regulation of lipopolysaccharide-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of tumor necrosis factor productionISS:UniProtKB
Response to lipopolysaccharideManual Assertion Based On ExperimentIDA:MGI
Toll-like receptor 4 signaling pathwayISS:UniProtKB
Toll-like receptor signaling pathwayManual Assertion Based On ExperimentIDA:ComplexPortal
Cellular Location
Secreted, extracellular space
Secreted
Retained in the extracellular space at the cell surface by interaction with TLR4 (PubMed:10359581).
PTM
N-glycosylated; high-mannose.
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Anti-LY96 antibodies

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Mouse Anti-LY96 Recombinant Antibody (A964) (CBMAB-AP4442LY)

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Target: LY96
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: A964
Application*: ELISA, IHC, WB
Datasheet SDS

Mouse Anti-LY96 Recombinant Antibody (A963) (CBMAB-AP4441LY)

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Target: LY96
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: A963
Application*: ELISA, IHC, WB
Datasheet SDS

Recombinant Mouse Anti-LY96 Antibody (CBHb283) (CBMAB-Hb761-LY)

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Target: LY96
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBHb283
Application*: FC, FuncS
Datasheet SDS

Recombinant Mouse Anti-LY96 Antibody (CBHb282) (CBMAB-Hb981-LY)

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Target: LY96
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBHb282
Application*: FC, FuncS, Immuno assays, IF, WB
Datasheet SDS

Mouse Anti-LY96 Recombinant Antibody (CBFYM-1241) (CBMAB-M1398-FY)

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Target: LY96
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-1241
Application*: WB, E, FN, IF
Datasheet SDS

Mouse Anti-LY96 Recombinant Antibody (CBFYM-1240) (CBMAB-M1397-FY)

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Target: LY96
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYM-1240
Application*: IF, FN
Datasheet SDS

Mouse Anti-LY96 (AA 17-160) Recombinant Antibody (CBFYM-1239) (CBMAB-M1396-FY)

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Target: LY96
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-1239
Application*: WB
Datasheet SDS

Mouse Anti-LY96 Recombinant Antibody (CBFYM-1238) (CBMAB-M1395-FY)

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Target: LY96
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-1238
Application*: E, WB
Datasheet SDS

Mouse Anti-LY96 Recombinant Antibody (CBFYM-0167) (CBMAB-M0190-FY)

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Target: LY96
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-0167
Application*: E, IF, WB, FN
Datasheet SDS

Mouse Anti-LY96 Recombinant Antibody (CBFYM-0074) (CBMAB-M0084-FY)

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Target: LY96
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYM-0074
Application*: FN
Datasheet SDS

Mouse Anti-LY96 Recombinant Antibody (CBFYM-0073) (CBMAB-M0083-FY)

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Target: LY96
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYM-0073
Application*: FN, F
Datasheet SDS

Mouse Anti-LY96 Recombinant Antibody (CBFYM-0052) (CBMAB-M0058-FY)

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Target: LY96
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-0052
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-LY96 Recombinant Antibody (CBYCL-581) (CBMAB-L0482-YC)

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Target: LY96
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: CBYCL-581
Application*: E, WB, IH
Datasheet SDS

Mouse Anti-LY96 Recombinant Antibody (CBYJL-2223) (CBMAB-L2471-YJ)

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Target: LY96
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-2223
Application*: WB
Datasheet SDS

Mouse Anti-LY96 Recombinant Antibody (CBYJL-2222) (CBMAB-L2470-YJ)

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Target: LY96
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-2222
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-LY96 Recombinant Antibody (9F1B1) (CBMAB-L2469-YJ)

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Target: LY96
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: 9F1B1
Application*: E, P, WB
Datasheet SDS

Mouse Anti-LY96 Recombinant Antibody (CBYJL-2221) (CBMAB-L2468-YJ)

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Target: LY96
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJL-2221
Application*: F
Datasheet SDS

Mouse Anti-LY96 Recombinant Antibody (CBYJL-2220) (CBMAB-L2467-YJ)

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Target: LY96
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-2220
Application*: E, FN, IF, WB
Datasheet SDS

Mouse Anti-LY96 Recombinant Antibody (1A2E3) (CBMAB-L2466-YJ)

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Target: LY96
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1A2E3
Application*: E, P, WB
Datasheet SDS

Mouse Anti-LY96 Recombinant Antibody (18H10) (CBMAB-L2465-YJ)

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Target: LY96
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 18H10
Application*: F
Datasheet SDS

Mouse Anti-LY96 Recombinant Antibody (13L23) (CBMAB-L2464-YJ)

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Target: LY96
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 13L23
Application*: E, IH, WB
Datasheet SDS

Mouse Anti-LY96 Recombinant Antibody (13L22) (CBMAB-L2463-YJ)

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Target: LY96
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: 13L22
Application*: E, IF, IH, WB
Datasheet SDS

Mouse Anti-LY96 Recombinant Antibody (13A77) (CBMAB-L2462-YJ)

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Target: LY96
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 13A77
Application*: F
Datasheet SDS
More Infomation
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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