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LY96

This gene encodes a protein which associates with toll-like receptor 4 on the cell surface and confers responsiveness to lipopolysaccyaride (LPS), thus providing a link between the receptor and LPS signaling.

Full Name

LY96

Function

Binds bacterial lipopolysaccharide (LPS) (PubMed:17803912, PubMed:17569869).
Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria (PubMed:11160242, PubMed:11593030).
Enhances TLR4-dependent activation of NF-kappa-B (PubMed:10359581).
Cells expressing both LY96 and TLR4, but not TLR4 alone, respond to LPS (PubMed:10359581).

Biological Process

Cell surface receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Cellular defense responseManual Assertion Based On ExperimentTAS:ProtInc
Cellular response to lipopolysaccharideManual Assertion Based On ExperimentIBA:GO_Central
Detection of lipopolysaccharideManual Assertion Based On ExperimentIDA:UniProtKB
Inflammatory responseIEA:UniProtKB-KW
Innate immune response1 PublicationIC:ComplexPortal
Positive regulation of lipopolysaccharide-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of tumor necrosis factor productionISS:UniProtKB
Response to lipopolysaccharideManual Assertion Based On ExperimentIDA:MGI
Toll-like receptor 4 signaling pathwayISS:UniProtKB
Toll-like receptor signaling pathwayManual Assertion Based On ExperimentIDA:ComplexPortal

Cellular Location

Secreted, extracellular space
Secreted
Retained in the extracellular space at the cell surface by interaction with TLR4 (PubMed:10359581).

PTM

N-glycosylated; high-mannose.

Anti-LY96 antibodies

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Submit A Review

Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Mouse Anti-LY96 Recombinant Antibody (A964) (CBMAB-AP4442LY)

SDS

Target: LY96

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: A964

Application*: ELISA, IHC, WB

Mouse Anti-LY96 Recombinant Antibody (A963) (CBMAB-AP4441LY)

SDS

Target: LY96

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Mouse

Clone: A963

Application*: ELISA, IHC, WB

Recombinant Mouse Anti-LY96 Antibody (CBHb283) (CBMAB-Hb761-LY)

SDS

Target: LY96

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBHb283

Application*: FC, FuncS

Recombinant Mouse Anti-LY96 Antibody (CBHb282) (CBMAB-Hb981-LY)

SDS

Target: LY96

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBHb282

Application*: FC, FuncS, Immuno assays, IF, WB

Mouse Anti-LY96 Recombinant Antibody (CBFYM-1241) (CBMAB-M1398-FY)

SDS

Target: LY96

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYM-1241

Application*: WB, E, FN, IF

Mouse Anti-LY96 Recombinant Antibody (CBFYM-1240) (CBMAB-M1397-FY)

SDS

Target: LY96

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBFYM-1240

Application*: IF, FN

Mouse Anti-LY96 (AA 17-160) Recombinant Antibody (CBFYM-1239) (CBMAB-M1396-FY)

SDS

Target: LY96

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYM-1239

Application*: WB

Mouse Anti-LY96 Recombinant Antibody (CBFYM-1238) (CBMAB-M1395-FY)

SDS

Target: LY96

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYM-1238

Application*: E, WB

Mouse Anti-LY96 Recombinant Antibody (CBFYM-0167) (CBMAB-M0190-FY)

SDS

Target: LY96

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYM-0167

Application*: E, IF, WB, FN

Mouse Anti-LY96 Recombinant Antibody (CBFYM-0074) (CBMAB-M0084-FY)

SDS

Target: LY96

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBFYM-0074

Application*: FN

Mouse Anti-LY96 Recombinant Antibody (CBFYM-0073) (CBMAB-M0083-FY)

SDS

Target: LY96

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBFYM-0073

Application*: FN, F

Mouse Anti-LY96 Recombinant Antibody (CBFYM-0052) (CBMAB-M0058-FY)

SDS

Target: LY96

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYM-0052

Application*: E, IF, WB

Mouse Anti-LY96 Recombinant Antibody (CBYCL-581) (CBMAB-L0482-YC)

SDS

Target: LY96

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Mouse

Clone: CBYCL-581

Application*: E, WB, IH

Mouse Anti-LY96 Recombinant Antibody (CBYJL-2223) (CBMAB-L2471-YJ)

SDS

Target: LY96

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJL-2223

Application*: WB

Mouse Anti-LY96 Recombinant Antibody (CBYJL-2222) (CBMAB-L2470-YJ)

SDS

Target: LY96

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJL-2222

Application*: E, IF, WB

Mouse Anti-LY96 Recombinant Antibody (9F1B1) (CBMAB-L2469-YJ)

SDS

Target: LY96

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Mouse

Clone: 9F1B1

Application*: E, P, WB

Mouse Anti-LY96 Recombinant Antibody (CBYJL-2221) (CBMAB-L2468-YJ)

SDS

Target: LY96

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBYJL-2221

Application*: F

Mouse Anti-LY96 Recombinant Antibody (CBYJL-2220) (CBMAB-L2467-YJ)

SDS

Target: LY96

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJL-2220

Application*: E, FN, IF, WB

Mouse Anti-LY96 Recombinant Antibody (1A2E3) (CBMAB-L2466-YJ)

SDS

Target: LY96

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 1A2E3

Application*: E, P, WB

Mouse Anti-LY96 Recombinant Antibody (18H10) (CBMAB-L2465-YJ)

SDS

Target: LY96

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: 18H10

Application*: F

Mouse Anti-LY96 Recombinant Antibody (13L23) (CBMAB-L2464-YJ)

SDS

Target: LY96

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat

Clone: 13L23

Application*: E, IH, WB

Mouse Anti-LY96 Recombinant Antibody (13L22) (CBMAB-L2463-YJ)

SDS

Target: LY96

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse

Clone: 13L22

Application*: E, IF, IH, WB

Mouse Anti-LY96 Recombinant Antibody (13A77) (CBMAB-L2462-YJ)

SDS

Target: LY96

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 13A77

Application*: F

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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