LY96
This gene encodes a protein which associates with toll-like receptor 4 on the cell surface and confers responsiveness to lipopolysaccyaride (LPS), thus providing a link between the receptor and LPS signaling.
Full Name
LY96
Function
Binds bacterial lipopolysaccharide (LPS) (PubMed:17803912, PubMed:17569869).
Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria (PubMed:11160242, PubMed:11593030).
Enhances TLR4-dependent activation of NF-kappa-B (PubMed:10359581).
Cells expressing both LY96 and TLR4, but not TLR4 alone, respond to LPS (PubMed:10359581).
Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria (PubMed:11160242, PubMed:11593030).
Enhances TLR4-dependent activation of NF-kappa-B (PubMed:10359581).
Cells expressing both LY96 and TLR4, but not TLR4 alone, respond to LPS (PubMed:10359581).
Biological Process
Cell surface receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Cellular defense responseManual Assertion Based On ExperimentTAS:ProtInc
Cellular response to lipopolysaccharideManual Assertion Based On ExperimentIBA:GO_Central
Detection of lipopolysaccharideManual Assertion Based On ExperimentIDA:UniProtKB
Inflammatory responseIEA:UniProtKB-KW
Innate immune response1 PublicationIC:ComplexPortal
Positive regulation of lipopolysaccharide-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of tumor necrosis factor productionISS:UniProtKB
Response to lipopolysaccharideManual Assertion Based On ExperimentIDA:MGI
Toll-like receptor 4 signaling pathwayISS:UniProtKB
Toll-like receptor signaling pathwayManual Assertion Based On ExperimentIDA:ComplexPortal
Cellular defense responseManual Assertion Based On ExperimentTAS:ProtInc
Cellular response to lipopolysaccharideManual Assertion Based On ExperimentIBA:GO_Central
Detection of lipopolysaccharideManual Assertion Based On ExperimentIDA:UniProtKB
Inflammatory responseIEA:UniProtKB-KW
Innate immune response1 PublicationIC:ComplexPortal
Positive regulation of lipopolysaccharide-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of tumor necrosis factor productionISS:UniProtKB
Response to lipopolysaccharideManual Assertion Based On ExperimentIDA:MGI
Toll-like receptor 4 signaling pathwayISS:UniProtKB
Toll-like receptor signaling pathwayManual Assertion Based On ExperimentIDA:ComplexPortal
Cellular Location
Secreted, extracellular space
Secreted
Retained in the extracellular space at the cell surface by interaction with TLR4 (PubMed:10359581).
Secreted
Retained in the extracellular space at the cell surface by interaction with TLR4 (PubMed:10359581).
PTM
N-glycosylated; high-mannose.
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Anti-LY96 antibodies
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CompareTarget: LY96
Sensitivity: 0.024 ng/mL
Detection Range: 0.05-10 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Target: Ly96
Sensitivity: 0.026 ng/mL
Detection Range: 0.05-20 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Mouse
Assay Type: Sandwich
Reactivity: Mouse
Target: LY96
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-160
Tag: hFc Tag
Target: LY96
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: A964
Application*: ELISA, IHC, WB
Target: LY96
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: A963
Application*: ELISA, IHC, WB
Target: LY96
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBHb283
Application*: FC, FuncS
Target: LY96
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBHb282
Application*: FC, FuncS, Immuno assays, IF, WB
Target: LY96
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-1241
Application*: WB, E, FN, IF
Target: LY96
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYM-1240
Application*: IF, FN
Target: LY96
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-1239
Application*: WB
Target: LY96
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-1238
Application*: E, WB
Target: LY96
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-0167
Application*: E, IF, WB, FN
Target: LY96
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYM-0074
Application*: FN
Target: LY96
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYM-0073
Application*: FN, F
Target: LY96
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-0052
Application*: E, IF, WB
Target: LY96
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: CBYCL-581
Application*: E, WB, IH
Target: LY96
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-2223
Application*: WB
Target: LY96
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-2222
Application*: E, IF, WB
Target: LY96
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: 9F1B1
Application*: E, P, WB
Target: LY96
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJL-2221
Application*: F
Target: LY96
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-2220
Application*: E, FN, IF, WB
Target: LY96
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1A2E3
Application*: E, P, WB
Target: LY96
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 18H10
Application*: F
Target: LY96
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 13L23
Application*: E, IH, WB
Target: LY96
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: 13L22
Application*: E, IF, IH, WB
Target: LY96
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 13A77
Application*: F
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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