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Mouse Anti-LY96 Recombinant Antibody (CBYCL-581) (CBMAB-L0482-YC)

Provided herein is a Mouse monoclonal antibody against Human LY96. The antibody can be used for immunoassay techniques, such as ELISA, WB, IHC.
See all LY96 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
CBYCL-581
Antibody Isotype
IgG
Application
ELISA, WB, IHC

Basic Information

Immunogen
A recombinant protein corresponding to amino acids 2 to 160 of human MD-2
Specificity
Human, Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 2-160

Target

Full Name
LY96
Introduction
LY96 is a protein which associates with toll-like receptor 4 on the cell surface and confers responsiveness to lipopolysaccyaride (LPS), thus providing a link between the receptor and LPS signaling. Studies of the mouse ortholog suggest that this gene may be involved in endotoxin neutralization. encoding different isoforms.
Entrez Gene ID
Human23643
Mouse17087
UniProt ID
HumanQ9Y6Y9
MouseQ9JHF9
Alternative Names
MD2; MD-2; ESOP-1; ly-96
Function
Binds bacterial lipopolysaccharide (LPS) (PubMed:17803912, PubMed:17569869).
Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria (PubMed:11160242, PubMed:11593030).
Enhances TLR4-dependent activation of NF-kappa-B (PubMed:10359581).
Cells expressing both LY96 and TLR4, but not TLR4 alone, respond to LPS (PubMed:10359581).
Biological Process
Cell surface receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Cellular defense responseManual Assertion Based On ExperimentTAS:ProtInc
Cellular response to lipopolysaccharideManual Assertion Based On ExperimentIBA:GO_Central
Detection of lipopolysaccharideManual Assertion Based On ExperimentIDA:UniProtKB
Inflammatory responseIEA:UniProtKB-KW
Innate immune response1 PublicationIC:ComplexPortal
Positive regulation of lipopolysaccharide-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of tumor necrosis factor productionISS:UniProtKB
Response to lipopolysaccharideManual Assertion Based On ExperimentIDA:MGI
Toll-like receptor 4 signaling pathwayISS:UniProtKB
Toll-like receptor signaling pathwayManual Assertion Based On ExperimentIDA:ComplexPortal
Cellular Location
Secreted, extracellular space
Secreted
Retained in the extracellular space at the cell surface by interaction with TLR4 (PubMed:10359581).
PTM
N-glycosylated; high-mannose.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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