Mouse Recombinant LY96 protein, hFc Tag (V2LY-0526-LY8657)

Name: Mouse Recombinant LY96 protein, hFc Tag
SKU: V2LY-0526-LY8657
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Mouse

Tag

hFc Tag

Protein Construction

This product is Mouse Recombinant LY96 protein, hFc Tag consist of Amino Acid: 1-160 and predicts a molecular mass of 43.4 kDa.

Molecule Mass

43.4 kDa

Sequence

Amino Acid: 1-160

Species

Mouse

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>95% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile Tirs, NaCl, Glycerol

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

LY96

Function

Binds bacterial lipopolysaccharide (LPS) (PubMed:17803912, PubMed:17569869).
Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria (PubMed:11160242, PubMed:11593030).
Enhances TLR4-dependent activation of NF-kappa-B (PubMed:10359581).
Cells expressing both LY96 and TLR4, but not TLR4 alone, respond to LPS (PubMed:10359581).

Biological Process

Cell surface receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Cellular defense responseManual Assertion Based On ExperimentTAS:ProtInc
Cellular response to lipopolysaccharideManual Assertion Based On ExperimentIBA:GO_Central
Detection of lipopolysaccharideManual Assertion Based On ExperimentIDA:UniProtKB
Inflammatory responseIEA:UniProtKB-KW
Innate immune response1 PublicationIC:ComplexPortal
Positive regulation of lipopolysaccharide-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of tumor necrosis factor productionISS:UniProtKB
Response to lipopolysaccharideManual Assertion Based On ExperimentIDA:MGI
Toll-like receptor 4 signaling pathwayISS:UniProtKB
Toll-like receptor signaling pathwayManual Assertion Based On ExperimentIDA:ComplexPortal

Cellular Location

Secreted, extracellular space
Secreted
Retained in the extracellular space at the cell surface by interaction with TLR4 (PubMed:10359581).

PTM

N-glycosylated; high-mannose.

Li, W., Meng, X., Yu, T., Shi, X., Dong, W., Ruan, H., ... & Xiao, W. (2023). Gene LY96 is an M2 macrophage‐related biomarker and is associated with immunosuppression in renal cell carcinoma. MedComm–Oncology, 2(3), e52.

Nie, K., Li, J., Peng, L., Zhang, M., & Huang, W. (2022). Pan-cancer analysis of the characteristics of LY96 in prognosis and immunotherapy across human cancer. Frontiers in Molecular Biosciences, 9, 837393.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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