MAP3K3

This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

Mitogen-Activated Protein Kinase Kinase Kinase 3

Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators.

Blood vessel developmentIEA:Ensembl
Intracellular signal transductionManual Assertion Based On ExperimentIDA:MGI
MAPK cascadeManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of cellular senescenceManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of cell migration involved in sprouting angiogenesisManual Assertion Based On ExperimentIGI:BHF-UCL
Positive regulation of cell proliferation in bone marrowManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of I-kappaB kinase/NF-kappaB signalingManual Assertion Based On ExperimentIEP:UniProtKB
Positive regulation of p38MAPK cascadeIEA:Ensembl
Protein autophosphorylationManual Assertion Based On ExperimentIDA:MGI

Cytoplasm
Cytosol

Phosphorylation at Ser-166 and Ser-337 by SGK1 inhibits its activity.