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Mouse Anti-MAP3K3 Recombinant Antibody (1H3) (CBMAB-A5208-LY)

The product is antibody recognizes MAP3K3. The antibody 1H3 immunoassay techniques such as: WB, ELISA.
Host Species
Mouse
Application
WB, ELISA
Immunogen
MAP3K3 (AAH10464.1, 1 a.a. ~ 89 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Antibody Isotype
IgG2a, κ
Specificity
Human
Clone
1H3
Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
Introduction
This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq]
Alternative Name
MAPKKK3; MEKK3
Entrez Gene ID
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For Research Use Only. Not For Clinical Use.
Cat CBMAB-A5208-LY
Conjugates
Size
Price $
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Second antibody and isotype control