MAP4K1

MAP4K1 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 1) is a Protein Coding gene. Among its related pathways are Kit receptor signaling pathway and TGF-Beta Pathway. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAP4K5.

Full Name

mitogen-activated protein kinase kinase kinase kinase 1

Function

Serine/threonine-protein kinase, which may play a role in the response to environmental stress (PubMed:24362026).
Appears to act upstream of the JUN N-terminal pathway (PubMed:8824585).
May play a role in hematopoietic lineage decisions and growth regulation (PubMed:8824585, PubMed:24362026).
Able to autophosphorylate (PubMed:8824585).
Together with CLNK, it enhances CD3-triggered activation of T-cells and subsequent IL2 production (By similarity).

Biological Process

Cell population proliferationManual Assertion Based On ExperimentIMP:UniProtKB
Cellular response to phorbol 13-acetate 12-myristateManual Assertion Based On ExperimentIDA:UniProtKB
JNK cascadeManual Assertion Based On ExperimentIDA:UniProtKB
Peptidyl-serine phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of MAPK cascadeManual Assertion Based On ExperimentIDA:UniProtKB
Protein autophosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Protein phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Membrane

PTM

Autophosphorylates: phosphorylation promotes ubiquitination by the Cul7-RING(FBXW8) ubiquitin-protein ligase complex, leading to its degradation by the proteasome.
Tyrosine-phosphorylated after activation of hemopoietic cells.
Ubiquitinated by the Cul7-RING(FBXW8) ubiquitin-protein ligase complex following autophosphorylation, leading to its degradation by the proteasome.