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MCL1

This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing. [provided by RefSeq, Oct 2010]

Full Name

MCL1, BCL2 Family Apoptosis Regulator

Function

Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.

Biological Process

Cell fate determination Source: UniProtKB
Cellular homeostasis Source: UniProtKB
Extrinsic apoptotic signaling pathway in absence of ligand Source: UniProtKB
Intrinsic apoptotic signaling pathway in response to DNA damage Source: GO_Central
Negative regulation of anoikis Source: UniProtKB
Negative regulation of apoptotic process Source: BHF-UCL
Negative regulation of autophagy Source: UniProtKB
Negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: UniProtKB
Negative regulation of intrinsic apoptotic signaling pathway Source: GO_Central
Positive regulation of apoptotic process Source: ComplexPortal
Positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway Source: ParkinsonsUK-UCL
Regulation of apoptotic process Source: ComplexPortal
Regulation of response to DNA damage stimulus Source: MGI
Response to cytokine Source: MGI

Cellular Location

Mitochondrion
Cytoplasm
Nucleus
nucleoplasm
Other locations
Membrane
Note: Cytoplasmic, associated with mitochondria.

Topology

Helical: 328-348

PTM

Cleaved by CASP3 during apoptosis. In intact cells cleavage occurs preferentially after Asp-127, yielding a pro-apoptotic 28 kDa C-terminal fragment.
Rapidly degraded in the absence of phosphorylation on Thr-163 in the PEST region.
Phosphorylated on Ser-159, by GSK3, in response to IL3/interleukin-3 withdrawal. Phosphorylation at Ser-159 induces ubiquitination and proteasomal degradation, abrogating the anti-apoptotic activity. Treatment with taxol or okadaic acid induces phosphorylation on additional sites.
Ubiquitinated. Ubiquitination is induced by phosphorylation at Ser-159.

Anti-MCL1 antibodies

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Rabbit Anti-MCL1 Recombinant Antibody (A1029) (CBMAB-AP11679LY)

SDS

Target: MCL1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: A1029

Application*: FC, ICC, IF, IHC, WB

Rabbit Anti-MCL1 Recombinant Antibody (A1028) (CBMAB-AP11681LY)

SDS

Target: MCL1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: A1028

Application*: FC, ICC, IF, IHC, IP, WB

Mouse Anti-MCL1 Recombinant Antibody (A1027) (CBMAB-AP11683LY)

SDS

Target: MCL1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: A1027

Application*: ELISA, IF, IHC, WB

Mouse Anti-MCL1 Recombinant Antibody (CF283) (CBMAB-FT225LY)

SDS

Target: MCL1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CF283

Application*: ELISA, WB, IF, IHC

Mouse Anti-MCL1 Recombinant Antibody (8C6, 8C6D4B1) (CBMAB-AO733LY)

SDS

Target: MCL1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 8C6, 8C6D4B1

Application*: WB, IHC, IF

Recombinant Rabbit Anti-MCL1 Antibody (CBAb162) (CBMAB-Ab162-LY)

SDS

Target: MCL1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: CBAb162

Application*: WB, IH, IF, IP

Rabbit Anti-MCL1 Recombinant Antibody (D2W9E) (CBMAB-CP1470-LY)

SDS

Target: MCL1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: D2W9E

Application*: WB, IP, IF (IC), F

Rabbit Anti-MCL1 Recombinant Antibody (D5V5L) (CBMAB-CP1469-LY)

SDS

Target: MCL1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: D5V5L

Application*: WB, P, IF (IC)

Rabbit Anti-MCL1 (Phosphorylated T163) Recombinant Antibody (D5M9D) (PTM-CBMAB-0628LY)

SDS

Target: MCL1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: D5M9D

Application*: WB, IP

Rat Anti-MCL1 Recombinant Antibody (CBFYM-1884) (CBMAB-M2056-FY)

SDS

Target: MCL1

Host: Rat

Antibody Isotype: IgG2a, κ

Specificity: Mouse

Clone: CBFYM-1884

Application*: WB, IF

Rabbit Anti-MCL1 Recombinant Antibody (CBFYM-1883) (CBMAB-M2055-FY)

SDS

Target: MCL1

Host: Rabbit

Specificity: Human, Mouse, Rat

Clone: CBFYM-1883

Application*: F, IF, IP, WB

Rabbit Anti-MCL1 Recombinant Antibody (CBFYM-1882) (CBMAB-M2054-FY)

SDS

Target: MCL1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: CBFYM-1882

Application*: F

Rabbit Anti-MCL1 Recombinant Antibody (CBFYM-1881) (CBMAB-M2053-FY)

SDS

Target: MCL1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: CBFYM-1881

Application*: WB, P, IF, IP, F

Mouse Anti-MCL1 (AA 1-327) Recombinant Antibody (CBFYM-1880) (CBMAB-M2052-FY)

SDS

Target: MCL1

Host: Mouse

Specificity: Human

Clone: CBFYM-1880

Application*: E, IH, IP, WB

Mouse Anti-MCL1 (Center) Recombinant Antibody (CBFYM-1879) (CBMAB-M2051-FY)

SDS

Target: MCL1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYM-1879

Application*: P

Mouse Anti-MCL1 Recombinant Antibody (CBFYM-1878) (CBMAB-M2049-FY)

SDS

Target: MCL1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBFYM-1878

Application*: F, IF, IH, WB

Mouse Anti-MCL1 Recombinant Antibody (CBFYM-1877) (CBMAB-M2048-FY)

SDS

Target: MCL1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYM-1877

Application*: WB, IH, P

Mouse Anti-MCL1 Recombinant Antibody (CBFYM-1876) (CBMAB-M2047-FY)

SDS

Target: MCL1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBFYM-1876

Application*: WB, IF, F

Mouse Anti-MCL1 (AA 1-230) Recombinant Antibody (CBFYM-1875) (CBMAB-M2046-FY)

SDS

Target: MCL1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBFYM-1875

Application*: WB, IH

Mouse Anti-MCL1 Recombinant Antibody (CBFYM-1873) (CBMAB-M2044-FY)

SDS

Target: MCL1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYM-1873

Application*: E, C, P, IP, WB

Rabbit Anti-MCL1 Recombinant Antibody (CBFYM-1872) (CBMAB-M2043-FY)

SDS

Target: MCL1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Cattle, Human, Monkey, Mouse

Clone: CBFYM-1872

Application*: WB

Mouse Anti-MCL1 (AA 1-327) Recombinant Antibody (CBFYM-0790) (CBMAB-M0934-FY)

SDS

Target: MCL1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBFYM-0790

Application*: IP, WB

Rabbit Anti-MCL1 Recombinant Antibody (CBFYM-0603) (CBMAB-M0736-FY)

SDS

Target: MCL1

Host: Rabbit

Specificity: Human

Clone: CBFYM-0603

Application*: F, IF, IH, IP, WB

Rabbit Anti-MCL1 Recombinant Antibody (CBFYM-0449) (CBMAB-M0567-FY)

SDS

Target: MCL1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse, Rat, Human

Clone: CBFYM-0449

Application*: IF

Mouse Anti-MCL1 Recombinant Antibody (CBFYM-0341) (CBMAB-M0415-FY)

SDS

Target: MCL1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Mouse

Clone: CBFYM-0341

Application*: F, P

Mouse Anti-MCL1 Recombinant Antibody (CBFYM-0220) (CBMAB-M0264-FY)

SDS

Target: MCL1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYM-0220

Application*: E, WB, P, IF, F

Mouse Anti-MCL1 (C-terminus) Recombinant Antibody (22/Mcl-1) (CBMAB-M2050-FY)

SDS

Target: MCL1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 22/Mcl-1

Application*: WB, IP

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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