NDN

This intronless gene is located in the Prader-Willi syndrome deletion region. It is an imprinted gene and is expressed exclusively from the paternal allele. Studies in mouse suggest that the protein encoded by this gene may suppress growth in postmitotic neurons. [provided by RefSeq, Jul 2008]

Necdin, MAGE Family Member

Growth suppressor that facilitates the entry of the cell into cell cycle arrest. Functionally similar to the retinoblastoma protein it binds to and represses the activity of cell-cycle-promoting proteins such as SV40 large T antigen, adenovirus E1A, and the transcription factor E2F. Necdin also interacts with p53 and works in an additive manner to inhibit cell growth. Also functions as a transcription factor and directly binds to specific guanosine-rich DNA sequences (By similarity).

Axonal fasciculation Source: Ensembl
Axon extension Source: Ensembl
Central nervous system development Source: Ensembl
Genomic imprinting Source: Ensembl
Glial cell migration Source: Ensembl
Multicellular organismal homeostasis Source: Ensembl
Negative regulation of cell population proliferation Source: InterPro
Negative regulation of DNA-binding transcription factor activity Source: Ensembl
Negative regulation of transcription by RNA polymerase II Source: GO_Central
Neuron migration Source: Ensembl
Neurotrophin TRK receptor signaling pathway Source: Ensembl
Positive regulation of protein deacetylation Source: Ensembl
Post-embryonic development Source: Ensembl
Regulation of growth Source: UniProtKB-KW
Respiratory system process Source: Ensembl
Sensory perception of pain Source: Ensembl

Nucleus
Other locations
Perikaryon
Note: Neural perikarya, translocates to the nucleus of postmitotic neurons and interacts with the nuclear matrix.