Mouse Anti-NDN Recombinant Antibody (1B3) (CBMAB-N0207-WJ)

Name: Mouse Anti-NDN Recombinant Antibody (1B3)
SKU: CBMAB-N0207-WJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

1B3

Application

ELISA, IF, IHC, WB

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Necdin, MAGE Family Member

Introduction

This intronless gene is located in the Prader-Willi syndrome deletion region. It is an imprinted gene and is expressed exclusively from the paternal allele. Studies in mouse suggest that the protein encoded by this gene may suppress growth in postmitotic neurons. [provided by RefSeq, Jul 2008]

Entrez Gene ID

4692

UniProt ID

Q99608

Alternative Names

Necdin, MAGE Family Member; Necdin, Melanoma Antigen (MAGE) Family Member; Prader-Willi Syndrome Chromosome Region; Necdin Homolog (Mouse); Necdin-Like Protein; Necdin Homolog; HsT16328; Necdin; PWCR;

Function

Growth suppressor that facilitates the entry of the cell into cell cycle arrest. Functionally similar to the retinoblastoma protein it binds to and represses the activity of cell-cycle-promoting proteins such as SV40 large T antigen, adenovirus E1A, and the transcription factor E2F. Necdin also interacts with p53 and works in an additive manner to inhibit cell growth. Also functions as a transcription factor and directly binds to specific guanosine-rich DNA sequences (By similarity).

Biological Process

Axonal fasciculation Source: Ensembl
Axon extension Source: Ensembl
Central nervous system development Source: Ensembl
Genomic imprinting Source: Ensembl
Glial cell migration Source: Ensembl
Multicellular organismal homeostasis Source: Ensembl
Negative regulation of cell population proliferation Source: InterPro
Negative regulation of DNA-binding transcription factor activity Source: Ensembl
Negative regulation of transcription by RNA polymerase II Source: GO_Central
Neuron migration Source: Ensembl
Neurotrophin TRK receptor signaling pathway Source: Ensembl
Positive regulation of protein deacetylation Source: Ensembl
Post-embryonic development Source: Ensembl
Regulation of growth Source: UniProtKB-KW
Respiratory system process Source: Ensembl
Sensory perception of pain Source: Ensembl

Cellular Location

Nucleus
Other locations
Perikaryon
Note: Neural perikarya, translocates to the nucleus of postmitotic neurons and interacts with the nuclear matrix.

Arora, M., Kumari, S., Singh, J., Chopra, A., & Chauhan, S. S. (2020). Downregulation of brain enriched type 2 MAGEs is associated with immune infiltration and poor prognosis in glioma. Frontiers in oncology, 10, 573378.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Antibody Pairs

NDN Matched Antibody Pair (780) (CAT#: APMAB-780LY)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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