NRGN

Neurogranin (NRGN) is the human homolog of the neuron-specific rat RC3/neurogranin gene. This gene encodes a postsynaptic protein kinase substrate that binds calmodulin in the absence of calcium. The NRGN gene contains four exons and three introns. The exons 1 and 2 encode the protein and exons 3 and 4 contain untranslated sequences. It is suggested that the NRGN is a direct target for thyroid hormone in human brain, and that control of expression of this gene could underlay many of the consequences of hypothyroidism on mental states during development as well as in adult subjects. [provided by RefSeq, Jul 2008]

Full Name

Neurogranin

Function

Acts as a 'third messenger' substrate of protein kinase C-mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium (By similarity).

Biological Process

Associative learningIEA:Ensembl
Nervous system developmentManual Assertion Based On ExperimentTAS:ProtInc
Positive regulation of long-term synaptic potentiationIEA:Ensembl
Postsynaptic modulation of chemical synaptic transmissionIEA:Ensembl
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Telencephalon developmentIEA:Ensembl

Cellular Location

axon
cytosol
dendritic spine head
glutamatergic synapse
mitochondrial membrane
neuronal cell body
nucleus
postsynaptic density
postsynaptic membrane
trans-Golgi network transport vesicle membrane

PTM

Phosphorylated at Ser-36 by PHK and PKC, phosphorylation prevents interaction with Calmodulin and interrupts several learning- and memory-associated functions.