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Mouse Anti-NRGN Recombinant Antibody (CBWJN-1551) (CBMAB-N3588-WJ)

This product is a Mouse antibody that recognizes NRGN. The antibody CBWJN-1551 can be used for immunoassay techniques such as: IHC.
See all NRGN antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBWJN-1551
Antibody Isotype
IgG3
Application
IHC

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG3
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Neurogranin
Introduction
Neurogranin (NRGN) is the human homolog of the neuron-specific rat RC3/neurogranin gene. This gene encodes a postsynaptic protein kinase substrate that binds calmodulin in the absence of calcium. The NRGN gene contains four exons and three introns. The exons 1 and 2 encode the protein and exons 3 and 4 contain untranslated sequences. It is suggested that the NRGN is a direct target for thyroid hormone in human brain, and that control of expression of this gene could underlay many of the consequences of hypothyroidism on mental states during development as well as in adult subjects. [provided by RefSeq, Jul 2008]
Entrez Gene ID
Human4900
Mouse64011
Rat64356
UniProt ID
HumanQ92686
MouseP60761
RatQ04940
Alternative Names
Neurogranin; Neurogranin (Protein Kinase C Substrate, RC3); RC3; Calmodulin-Binding Protein; Protein Kinase C Substrate; Hng; Ng;
Function
Acts as a 'third messenger' substrate of protein kinase C-mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium (By similarity).
Biological Process
Associative learningIEA:Ensembl
Nervous system developmentManual Assertion Based On ExperimentTAS:ProtInc
Positive regulation of long-term synaptic potentiationIEA:Ensembl
Postsynaptic modulation of chemical synaptic transmissionIEA:Ensembl
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Telencephalon developmentIEA:Ensembl
Cellular Location
axon
cytosol
dendritic spine head
glutamatergic synapse
mitochondrial membrane
neuronal cell body
nucleus
postsynaptic density
postsynaptic membrane
trans-Golgi network transport vesicle membrane
PTM
Phosphorylated at Ser-36 by PHK and PKC, phosphorylation prevents interaction with Calmodulin and interrupts several learning- and memory-associated functions.

Rueda-García, V., & Rondón-Barragán, I. S. (2023). Molecular Characterization of Neurogranin (NRGN) Gene from Red‑Bellied Pacu (Piaractus brachypomus). Molecular Neurobiology, 1-11.

Hunter, K. (2023). Investigating the negative regulatory role of neurogranin in IgE-mediated mast cell activation.

Takahashi, Y., Ojiro, R., Yamashita, R., Shimizu, S., Maeda, N., Zou, X., ... & Shibutani, M. (2023). Suppression of neurogranin expression by disruption of epigenetic DNA methylation in hippocampal mature granule cells after developmental exposure to neurotoxicants in rats. Toxicology Letters, 390, 33-45.

Kalkan, A., Demirel, A., Atiş, Ş. E., Karaaslan, E. B., Ferhatlar, M. E., & Senturk, M. (2022). A new biomarker in the differential diagnosis of epileptic seizure: Neurogranin. The American Journal of Emergency Medicine, 54, 147-150.

Alba-González, A., Yáñez, J., Anadón, R., & Folgueira, M. (2022). Neurogranin-like immunoreactivity in the zebrafish brain during development. Brain Structure and Function, 227(8), 2593-2607.

Hwang, H., Szucs, M. J., Ding, L. J., Allen, A., Ren, X., Haensgen, H., ... & Xu, W. (2021). Neurogranin, encoded by the schizophrenia risk gene NRGN, bidirectionally modulates synaptic plasticity via calmodulin-dependent regulation of the neuronal phosphoproteome. Biological psychiatry, 89(3), 256-269.

Nakajima, R., Hattori, S., Funasaka, T., Huang, F. L., & Miyakawa, T. (2021). Decreased nesting behavior, selective increases in locomotor activity in a novel environment, and paradoxically increased open arm exploration in Neurogranin knockout mice. Neuropsychopharmacology reports, 41(1), 111-116.

Sun, X., Wang, Q., Blennow, K., Zetterberg, H., McCarthy, M., Loewenstein, D. A., ... & Zhang, B. (2021). Association of neurogranin gene expression with Alzheimer's disease pathology in the perirhinal cortex. Alzheimer's & dementia: translational research & clinical interventions, 7(1), e12162.

Sun, X., Wang, Q., Blennow, K., Zetterberg, H., McCathy, M., Loewenstein, D. A., ... & Zhang, B. (2020). Selective association of neurogranin gene expression with amyloid and tau pathology in the parahippocampal gyrus in Alzheimer’s disease: Human neuropathology/topography of pathology. Alzheimer's & dementia, 16, e041053.

Jin, L., An, Z., Xu, B., Mu, D., Fu, S., Hu, H., ... & Yi, Q. (2019). The association between rs12807809 polymorphism in neurogranin gene and risk of schizophrenia: a meta-analysis. Medicine, 98(51), e18518.

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For research use only. Not intended for any clinical use.

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