NTF3

The protein encoded by this gene is a member of the neurotrophin family, that controls survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NTF3-deficient mice generated by gene targeting display severe movement defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse. [provided by RefSeq, Jul 2008]

Neurotrophin 3

Seems to promote the survival of visceral and proprioceptive sensory neurons.

Activation of GTPase activityManual Assertion Based On ExperimentIDA:BHF-UCL
Activation of protein kinase B activityManual Assertion Based On ExperimentIDA:BHF-UCL
Cell-cell signalingManual Assertion Based On ExperimentTAS:ProtInc
Induction of positive chemotaxisManual Assertion Based On ExperimentIDA:BHF-UCL
MemoryManual Assertion Based On ExperimentIBA:GO_Central
Modulation of chemical synaptic transmissionManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of neuron apoptotic processManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of peptidyl-tyrosine phosphorylationManual Assertion Based On ExperimentIDA:BHF-UCL
Nerve developmentManual Assertion Based On ExperimentIBA:GO_Central
Nerve growth factor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Nervous system developmentManual Assertion Based On ExperimentTAS:ProtInc
Neuron projection morphogenesisManual Assertion Based On ExperimentIBA:GO_Central
Peripheral nervous system developmentManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of actin cytoskeleton reorganizationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of cell migrationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of cell population proliferationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of MAP kinase activityManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of peptidyl-serine phosphorylationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of peptidyl-tyrosine phosphorylationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of receptor internalizationManual Assertion Based On ExperimentIDA:BHF-UCL
Regulation of apoptotic processManual Assertion Based On ExperimentIGI:MGI
Regulation of neuron differentiationManual Assertion Based On ExperimentIBA:GO_Central
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Transmembrane receptor protein tyrosine kinase signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL

Secreted