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Mouse Anti-NTF3 Recombinant Antibody (3D4) (CBMAB-N3716-WJ)

This product is a Mouse antibody that recognizes NTF3. The antibody 3D4 can be used for immunoassay techniques such as: IHC, WB.
See all NTF3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3D4
Antibody Isotype
IgG2a
Application
IHC, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.3, 1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Concentration
0.37 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Neurotrophin 3
Introduction
The protein encoded by this gene is a member of the neurotrophin family, that controls survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NTF3-deficient mice generated by gene targeting display severe movement defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse. [provided by RefSeq, Jul 2008]
Entrez Gene ID
4908
UniProt ID
P20783
Alternative Names
Neurotrophin 3; Nerve Growth Factor 2; Neurotrophic Factor; NGF-2; HDNF; NT-3; Neurotrophin-3; NGF2; NT3;
Function
Seems to promote the survival of visceral and proprioceptive sensory neurons.
Biological Process
Activation of GTPase activityManual Assertion Based On ExperimentIDA:BHF-UCL
Activation of protein kinase B activityManual Assertion Based On ExperimentIDA:BHF-UCL
Cell-cell signalingManual Assertion Based On ExperimentTAS:ProtInc
Induction of positive chemotaxisManual Assertion Based On ExperimentIDA:BHF-UCL
MemoryManual Assertion Based On ExperimentIBA:GO_Central
Modulation of chemical synaptic transmissionManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of neuron apoptotic processManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of peptidyl-tyrosine phosphorylationManual Assertion Based On ExperimentIDA:BHF-UCL
Nerve developmentManual Assertion Based On ExperimentIBA:GO_Central
Nerve growth factor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Nervous system developmentManual Assertion Based On ExperimentTAS:ProtInc
Neuron projection morphogenesisManual Assertion Based On ExperimentIBA:GO_Central
Peripheral nervous system developmentManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of actin cytoskeleton reorganizationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of cell migrationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of cell population proliferationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of MAP kinase activityManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of peptidyl-serine phosphorylationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of peptidyl-tyrosine phosphorylationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of receptor internalizationManual Assertion Based On ExperimentIDA:BHF-UCL
Regulation of apoptotic processManual Assertion Based On ExperimentIGI:MGI
Regulation of neuron differentiationManual Assertion Based On ExperimentIBA:GO_Central
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Transmembrane receptor protein tyrosine kinase signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Cellular Location
Secreted

Tan, J. W., An, J. J., Deane, H., Xu, H., Liao, G. Y., & Xu, B. (2024). Neurotrophin-3 from the dentate gyrus supports postsynaptic sites of mossy fiber-CA3 synapses and hippocampus-dependent cognitive functions. Molecular Psychiatry, 1-13.

Trinh, V. Q. H., Lee, T. F., Lemoinne, S., Ray, K. C., Ybanez, M. D., Tsuchida, T., ... & Lee, Y. A. (2023). Hepatic stellate cells maintain liver homeostasis through paracrine neurotrophin-3 signaling that induces hepatocyte proliferation. Science signaling, 16(787), eadf6696.

Omar, N. A., Kumar, J., & Teoh, S. L. (2022). Neurotrophin-3 and neurotrophin-4: The unsung heroes that lies behind the meninges. Neuropeptides, 92, 102226.

Yang, Z., Zhang, H., Yin, M., Cheng, Z., Jiang, P., Feng, M., ... & Liu, Z. (2022). Neurotrophin3 promotes hepatocellular carcinoma apoptosis through the JNK and P38 MAPK pathways. International Journal of Biological Sciences, 18(15), 5963.

Cassinotti, L. R., Ji, L., Borges, B. C., Cass, N. D., Desai, A. S., Kohrman, D. C., ... & Corfas, G. (2022). Cochlear Neurotrophin‐3 overexpression at mid‐life prevents age‐related inner hair cell synaptopathy and slows age‐related hearing loss. Aging Cell, 21(10), e13708.

Bilgiç, A., Ferahkaya, H., Kilinç, İ., & Energin, V. M. (2021). Serum Brain-Derived Neurotrophic Factor, Glial-Derived Neurotrophic Factor, Nerve Growth Factor and Neurotrophin-3 Levels in Preschool Children with Language Disorder. Archives of Neuropsychiatry, 58(2), 128.

Zhao, S., Chen, A., Cao, J., Wang, Z., Hu, W., Zhou, F., ... & Yu, H. (2020). Neurotrophin 3 hinders the growth and metastasis of hepatocellular carcinoma cells. Oncology and Translational Medicine, 6(4), 143-152.

Yang, Q. X., Liu, T., Yang, J. L., Liu, F., Chang, L., Che, G. L., ... & Jiang, Y. M. (2020). Low expression of NTF3 is associated with unfavorable prognosis in hepatocellular carcinoma. International Journal of Clinical and Experimental Pathology, 13(9), 2280.

Skibinska, M., Kapelski, P., Rajewska-Rager, A., Szczepankiewicz, A., Narozna, B., Duda, J., ... & Pawlak, J. (2019). Correlation of metabolic parameters, neurotrophin-3, and neurotrophin-4 serum levels in women with schizophrenia and first-onset depression. Nordic journal of psychiatry, 73(2), 96-103.

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For research use only. Not intended for any clinical use.

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