NTN1

Netrin is included in a family of laminin-related secreted proteins. The function of this gene has not yet been defined; however, netrin is thought to be involved in axon guidance and cell migration during development. Mutations and loss of expression of netrin suggest that variation in netrin may be involved in cancer development. [provided by RefSeq]

netrin 1

Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. Binding to UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (PubMed:28483977).
Involved in dorsal root ganglion axon projection towards the spinal cord (PubMed:28483977).
It also serves as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis (PubMed:15343335).

Animal organ morphogenesisManual Assertion Based On ExperimentIBA:GO_Central
Anterior/posterior axon guidanceIEA:Ensembl
Apoptotic processIEA:UniProtKB-KW
Cdc42 protein signal transductionISS:UniProtKB
Cell-cell adhesionIEA:Ensembl
Chemorepulsion of axonISS:UniProtKB
Dendrite developmentManual Assertion Based On ExperimentIBA:GO_Central
Inner ear morphogenesisIEA:Ensembl
Mammary gland duct morphogenesisIEA:Ensembl
Motor neuron axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of axon extensionIEA:Ensembl
Neuron migrationIEA:Ensembl
Nuclear migrationIEA:Ensembl
Positive regulation of axon extensionISS:UniProtKB
Positive regulation of cell motilityISS:UniProtKB
Positive regulation of cell population proliferationIEA:Ensembl
Ras protein signal transductionISS:UniProtKB
Regulation of cell migrationIEA:Ensembl
Regulation of synapse assemblyIEA:Ensembl
Substrate-dependent cell migration, cell extensionISS:UniProtKB
Tissue developmentManual Assertion Based On ExperimentIBA:GO_Central

Secreted
Cytoplasm
Mainly secreted.

Mirror movements 4 (MRMV4):
A disorder characterized by contralateral involuntary movements that mirror voluntary ones. While mirror movements are occasionally found in young children, persistence beyond the age of 10 is abnormal. Mirror movements occur more commonly in the upper extremities. MRMV4 inheritance is autosomal dominant.